Adjunctive quetiapine may help fluvoxamine-resistant obsessive-compulsive disorder among female in-patients: A randomized-controlled study

Figures & data

Figure 1. Changes of YBOCS between week 0 (baseline) and 12.

Figure 2. Changes of CGI-S between week 0 (baseline) and 12.

Table 1. Demographic and clinical characteristics of participants.

Groups Variables	Aripiprazole	Quetiapine	Df	T	P
Gender (female)	22	22		–	–
Age (Mean of yrs.)	38.45+/−8.47(S.D), 1.81(S.E)	39.27+/−9.08(S.D), 1.94(S.E)	42	0.21	0.82
Duration of illness (Mean of yrs.)	10.36+/−6.54(S.D), 1.39(S.E)	9.90+/−7.51(S.D), 1.60(S.E)	42	0.15	0.87
YBOCS-Baseline	33.17 +/−3.90(S.D), 0.83(S.E)	31.18+/−4.93(S.D), 1.05(S.E)	42	1.55	0.12
CGI-S-Baseline	3.29+/- 0.33(SD), 0.07(S.E)	3.38+/−0.08(SD), 0.02(S.E)	42	1.32	0.19

Notes: YBOCS: Yale-Brown Obsessive-Compulsive Scale; CGI-S: Clinical Global Impressions-Severity Scale; SD: Standard Deviation; SE: S.E.Mean; yrs.: years.

Table 2. Percentage of positive response on the YBOCS, in the aripiprazole and quetiapine groups.

No of patient	Quetiapine YBOCS (Baseline)	Quetiapine YBOCS (Endpoint)	Quetiapine % Change	Aripiprazole YBOCS (Baseline)	Aripiprazole YBOCS (Endpoint)	Aripiprazole % Change
1	38	25	34.21	31	23	25.8
2	29	21	27.58	40	29	27.51
3	35	23	34.28	32	23	28.12
4	31	23	25.8	42	31	26.19
5	30	22	26.66	29	21	27.58
6	37	26	29.72	31	23	25.8
7	35	24	31.42	–	–	–
8	38	27	28.94	–	–	–
9	29	22	24.13	–	–	–
10	31	23	25.8	–	–	–
11	30	22	26.66	–	–	–

Notes: YBOCS: Yale-Brown Obsessive-Compulsive Scale.

Table 3. Between-group analysis of primary outcome measure at baseline and weeks 2, 4, 8 and 12.

Groups Primary Outcome Measure	Aripiprazole N = 22	Quetiapine N = 22	T	P	Df	95% CI
YBOCS-Baseline	33.17 +/−3.90(S.D), 0.83(S.E)	31.18+/− .93(S.D), 1.05(S.E)	1.48	0.14	42	−0.71, 4.69
YBOCS –week 2	32.36+/−4.81(S.D), 1.03(S.E)	30.02+/−.51(S.D), 0.75(S.E)	1.84	0.07	42	−0.22, 4.90
YBOCS –week 4	31.19+/−3.75(SD), 0.80(SE)	29.43+/−.26(SD), 0.70(SE)	1.66	0.10	42	−0.38, 3.90
YBOCS –week 8	30.53+/−4.11(S.D), 0.88(S.E)	27.68+/−.95(S.D), 1.27(S.E)	1.84	0.08	42	−0.26, 5.96
YBOCS-week 12	30.72+/−4.67(SD), 1.00(S.E)	27.97+/−.71(S.D), 0.79(S.E)	2.163	0.03	42	0.18, 5.32

Notes: YBOCS: Yale-Brown Obsessive Compulsive Scale, OCD: obsessive-compulsive disorder; SD: Standard Deviation; SE: SE Mean.