ABSTRACT
Background
Prior studies have reported a lower retinal vessel density (RVD) in amblyopic vs. non-amblyopic eyes. No studies have shown if amblyopic eye RVD changes following patching therapy. We assessed for RVD differences between pre-treatment vs. post-treatment amblyopic eyes.
Methods
Participants were included if they were <10 years old with unilateral amblyopia. All subjects were required to visit the pediatric eye clinic for examination. Exclusion criteria included: deprivation amblyopia, bilateral amblyopia, nystagmus, media opacity, intraocular inflammation, or any retinal disease. All participants underwent optical coherence tomography angiography (OCTA) before and after refraction and patching treatment. Outcomes included superficial (SCP) and deep (DCP) capillary plexus RVD.
Results
12 patients (12 amblyopic eyes) were included. Mean (SD) age, gestational age (GA), birth weight (BW), and follow-up time were: 6.5 (1.7) years, 39.4 weeks (1.4 w), 3271 g (262 g), and 114 days (46d), respectively. There was a significant increase in the RVD of the DCP in 3 × 3-mm scans after treatment, specifically in the whole image (52.6 ± 5.75 vs 56.5 ± 2.48%, p = .046) and superior hemisphere regions (52.47 ± 6.17 vs 56.73 ± 2.27%, p = .048).
Conclusions
Amblyopic eye RVD potentially increases after amblyopia treatment in specific regions of the retina. Further research is required to refine this clinical parameter.
Financial disclosures
In accordance with Journal of Binocular Vision and Ocular Motility policy and my ethical obligation as a researcher, I am reporting that I along with my co-authors have no financial disclosures to report for any author except for those
that are stated explicitly below. I have disclosed those interests fully to the journal, and I have in place an approved plan for managing any potential conflicts arising from that involvement.
Dr. David Sarraf: Amgen (C), Bayer (C), Genentech (C,F), Heidelberg (F), Novartis (C), Regeneron (F), Optovue (C,F), Topcon (F).
Supplementary material
Supplemental data for this article can be accessed on publisher’s website