Recent findings regarding the effects of microRNAs on fibroblast-like synovial cells in rheumatoid arthritis

Figures & data

Table 1. The summary of individual miRNAs in RA-FLS.

microRNA	Targets	Expression in RA-FLS	Related pathway	Reference
miR-203	Not identified	Upregulated	NF-κB signaling	[15]
miR-20a	ASK1	Downregulated in response to LPS	TLR signaling	[16]
miR-346	BTK	Upregulated in response to LPS		[17,18]
miR-17	TRAF2, cIAP1	Downregulated in synovial tissue	NF-κB signaling	[19]
miR-19	TNFAIP3, Rnfl1	Downregulated in response to LPS	TLR signaling NF-κB signaling	[20,21]
miR-18a	TNFAIP3	Upregulated in response to TNF-α	NF-κB signaling	[23]
miR-10a	IRAK4,TAK1,BTRC	Downregulated	NF-κB signaling	[24]
miR-34a*	XIAP	Downregulated		[25]
miR-155	IKBKE	Upregulated		[26]
miR-15a	Bcl-2	Downregulated		[27,28]
miR-221	XIAP	Upregulated in response to LPS		[29]
miR-663	APC	Upregulated	Wnt signaling	[30]
miR-124a	CDK2	Downregulated		[31]
miR-188	Not identified	Downregulated		[33]
miR-126	PIK3R2	Upregulated in synovial tissue	PI3K-AKT signaling	[34]
miR-191	C/EBPβ	Upregulated in hypoxia environment		[36]
miR-29	DNMT3	DNA-methylation related		[40]
miR-152	DNMT1	DNA-methylation related	Wnt signaling	[41]
miR-218	ROBO1	Upregulated during osteogenic differentiation	Wnt signaling	[45]

ASK: apoptosis signal-regulating kinase; LPS: lipopolysaccharide; TLR: Toll-like receptor; BTK: Bruton’s tyrosine kinase; TRAF: TNF receptor associated factor; cIAP: cellular inhibitor of apoptosis protein; TNFAIP: tumor necrosis factor alpha-induced protein; IRAK: interleukin-1 receptor-associated kinase; TAK TGF-β-activated kinase; BTRC: β-transducing repeat-containing protein; XIAP: X-linked inhibitor of apoptosis; IKBKE: Inhibitor of Nuclear Factor Kappa B Kinase Subunit Epsilon; Bcl: B cell lymphoma; APC: adenomatous polyposis coli; CDK2: cyclin-dependent kinase; PIK3R: phosphatidylinositol 3-kinase regulatory subunit beta; C/EBPβ: CCAAT/enhancer binding protein β; DNMT: DNA methyltransferase; ROBO1: Roundabout1.

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