Figures & data
Table 1. Representative histone modification enzymes and their functions [Citation51–60].
Table 2. Components of ATP-dependent nucleosome remodeling complexes [Citation14–17].
Figure 1. Epigenetic regulation of skin immunity. Epigenetic dysregulation of either or both immune and non-immune cells affects the homeostatic balance between these cells via immune-regulatory factors. Disruption of homeostasis induces a skewed immune response. Establishment of epigenetic milieu leads to disease development of chronic cutaneous immune diseases.
Figure 2. Proposed model of epigenetic regulation in the development and progression of cutaneous immune diseases. Epigenetic regulators and DNA-binding transcription factors (TFs) are mutually recruited to genomic regulatory regions. Interplay between epigenetic regulators and TFs activates target genes associated with the disease. Epigenetic regulators include histone modifying enzymes and chromatin remodeling complexes. TFs and disease-related genes of atopic dermatitis and psoriasis are presented as representative.
