Albuterol combined with tiotropium bromide to improve the conditions and pulmonary functions of patients with acute exacerbation of chronic obstructive pulmonary disease

Figures & data

Table 1. Intergroup comparison of basic materials.

Type	OG(n = 38)	CG(n = 34)	t/χ^2	P
Gender			0.076	0.782
Male	20(52.63)	19(55.88)
Female	18(47.37)	15(44.12)
Age (y)	56.67 ± 7.58	55.52 ± 5.49	0.730	0.468
BMI(kg/m^2)	24.42 ± 1.34	23.85 ± 1.49	1.709	0.092
Domicile			0.422	0.673
Urban	22(57.89)	18(52.94)
Rural	16(42.11)	16(47.06)
History of Smoking			0.888	0.346
Yes	24(63.16)	25(73.53)
No	14(36.84)	9(26.47)
Exercise Habit			1.158	0.282
Yes	17(44.74)	11(32.35)
No	21(55.26)	23(67.65)
History of Drinking Alcohol			0.134	0.715
Yes	15(39.47)	12(35.29)
No	23(60.53)	22(64.71)
Course of Disease (y)	8.72 ± 1.32	8.69 ± 1.16	0.102	0.919
Grading			0.518	0.772
I	5(13.16)	3(8.82)
II	21(55.26)	19(55.88)
III	11(28.95)	12(35.29)

Figure 1. Intergroup comparison of results of blood gas analysis.

Note: *p < 0.05 vs conditions before treatment; #p < 0.05 vs OG after treatment.

Figure 2. Intergroup comparison of PF indexes.

Note: *p < 0.05 vs conditions before treatment; #p < 0.05 vs OG after treatment.

Table 2. Intergroup comparison of efficacy.

Type	OG (n = 38)	CG (n = 34)	χ^2	P
Markedly effective	9(23.68)	4(11.76)	4.086	0.043
Effective	25(65.79)	20(58.82)
Ineffective	4(10.53)	10(29.41)
OR	34(89.47)	24(70.59)

Table 3. Intergroup comparison of incidences of adverse reactions.

Type	OG (n = 38)	CG(n = 34)	χ^2 value	P
Dry mouth	1(2.63)	2(5.88)
Palpitation	1(2.63)	(0)
Nausea	2(5.26)	(0)
Constipation	1(2.63)	1(2.94)
Total incidence	4(10.53)	3(8.82)	0.059	0.808

Table 4. Intergroup comparison of SGRQ scores before and after treatment.

Group	Before treatment	After treatment
OG (n = 38)	58.89 ± 47	42.14 ± 4.32*
CG(n = 34)	58.16 ± 5.31	49.55 ± 3.97*
T	0.095	4.086
P	0.925	0.043

Note: *p < 0.05 vs conditions before treatment; 6.23 ± 0.41 4.95 ± 0.23 6.79 ± 0.45

Table 5. Intergroup comparison of time to improve clinical symptoms (d).

Group	Time to eliminate cough	Time to eliminate gasping	Time to eliminate lung rales
OG (n = 38)	5.17 ± 0.38	3.37 ± 0.18	4.82 ± 0.27
CG(n = 34)	6.23 ± 0.41	4.95 ± 0.23	6.79 ± 0.45
t	11.34	32.19	22.19
P	<0.01	<0.01	<0.01

Figure 3. Intergroup comparison of MMRC before and after treatment.

Note: *p < 0.05 vs conditions before treatment; #p < 0.05 vs OG after treatment.