The fasting plasma glucose is correlated to the prevalence and severity of coronary artery disease in population without diabetes history in Xinjiang, China

Figures & data

Table 1. The demography and clinical indexes in different ethnic populations with or without CAD.

	All of the cases (n = 1500)			Han (n = 587)			Uyghur (n = 502)			Kazahk p (n = 411)
	CHD − (n = 405)	CHD + (n = 1095)	P	CHD − (n = 136)	CHD + (n = 451)	P	CHD − (n = 138)	CHD + (n = 364)	P	CHD − (n = 131)	CHD + (n = 280)	P
Age, years	53.9 ± 10.55	58.98 ± 10.24	<.001	55.49 ± 11.31	60.81 ± 10.47	<.001	51.24 ± 9.49	56.71 ± 9.61	<.001	55.05 ± 10.32	59.00 ± 10.11	<.001
Male sex	251 (62.0%)	817 (74.6%)	<.001	79 (58.1%)	318 (70.5%)	.007	84 (60.9%)	283 (77.7%)	<.001	88 (67.2%)	216 (77.1%)	.032
Smoking	131 (32.3%)	575 (52.5%)	<.001	45 (33.1%)	227 (50.3%)	<.001	36 (26.1%)	182 (50.0%)	<.001	50 (38.2%)	166 (59.3%)	<.001
Hypertension	177 (43.8%)	653 (59.6%)	<.001	57 (41.9%)	276 (61.2%)	<.001	60 (43.8%)	203 (55.8%)	.017	60 (45.8%)	174 (62.1%)	.002
HbAlc (%)	2.22 ± 0.34	2.28 ± 0.49	.006	2.29 ± 0.41	2.31 ± 0.51	.624	2.16 ± 0.31	2.24 ± 0.51	.024	2.20 ± 0.28	2.27 ± 0.45	.063
Tbil (mmol/L)	12.53 ± 5.42	12.61 ± 5.77	.811	12.84 ± 5.22	12.88 ± 5.79	.947	11.52 ± 4.54	11.91 ± 5.45	.460	13.28 ± 6.29	13.10 ± 6.08	.782
Urea (mmol/L)	5.48 ± 1.55	5.53 ± 2.38	.714	5.39 ± 1.49	5.58 ± 3.29	.521	5.46 ± 1.56	5.47 ± 1.46	.936	5.60 ± 1.60	5.52 ± 1.43	.626
TG (mmol/L)	1.75 ± 1.23	1.85 ± 1.57	.265	1.66 ± 1.07	1.88 ± 1.80	.188	1.9 ± 1.45	1.76 ± 1.1	.317	1.69 ± 1.13	1.91 ± 1.68	.166
TC (mmol/L)	4.07 ± 1.00	3.80 ± 1.00	<.001	3.96 ± 0.98	3.78 ± 1.01	.068	4.13 ± 1.16	3.73 ± 1.02	<.001	4.14 ± 0.82	3.95 ± 0.96	.040
LDL-C (mmol/L)	2.67 ± 0.85	2.46 ± 0.85	<.001	2.58 ± 0.84	2.41 ± 0.86	.042	2.76 ± 0.98	2.48 ± 0.86	.002	2.67 ± 0.71	2.52 ± 0.84	.064
HDL-C (mmol/L)	1.09 ± 0.30	1.02 ± 0.30	<.001	1.14 ± 0.31	1.06 ± 0.31	.011	1.01 ± 0.29	0.95 ± 0.25	.019	1.13 ± 0.28	1.06 ± 0.31	.038

Table 2. The clinical indexes in different ethnic populations classified by the serum FPG levels.

	FPG (mmol/L)
Variables	<5.6	5.6–6.1	6.1–7.0	≥7.0	P-value
All patients
HbAlc (%)	2.17 ± 0.36	2.19 ± 0.35	2.32 ± 0.40	2.52 ± 0.63	<.001
Tbil (mmol/L)	12.70 ± 5.67	12.66 ± 5.78	12.36 ± 5.81	12.36 ± 5.62	.781
Urea (mmol/L)	5.44 ± 1.46	5.53 ± 1.59	5.98 ± 5.2	5.51 ± 1.72	.052
TG (mmol/L)	1.65 ± 1.46	1.82 ± 1.18	2.10 ± 1.49	2.18 ± 1.61	<.001
TC (mmol/L)	3.86 ± 1.02	4.00 ± 0.91	3.94 ± 1.06	3.84 ± 1.00	.338
LDL-C(mmol/L)	2.51 ± 0.86	2.65 ± 0.78	2.55 ± 0.92	2.47 ± 0.85	.179
HDL-C(mmol/L)	1.09 ± 0.31	1.00 ± 0.29	0.98 ± 0.27	0.98 ± 0.26	<.001
Han patients
HbAlc (%)	2.21 ± 0.42	2.31 ± 0.43	2.43 ± 0.42	2.54 ± 0.62	<.001
Tbil (mmol/L)	12.96 ± 5.76	13.02 ± 5.94	12.27 ± 5.45	12.84 ± 5.40	.857
Urea (mmol/L)	5.38 ± 1.50	5.44 ± 1.66	6.63 ± 8.17	5.51 ± 1.87	.032
TG (mmol/L)	1.65 ± 1.64	1.64 ± 0.95	2.14 ± 1.69	2.28 ± 1.82	.001
TC (mmol/L)	3.78 ± 1.01	3.89 ± 0.78	3.94 ± 0.96	3.84 ± 1.08	.672
LDL-C (mmol/L)	2.43 ± 0.86	2.55 ± 0.60	2.55 ± 0.90	2.43 ± 0.92	.628
HDL-C (mmol/L)	1.12 ± 0.33	1.08 ± 0.27	0.98 ± 0.25	1.01 ± 0.24	<.001
Uyghur patients
HbAlc (%)	2.12 ± 0.31	2.12 ± 0.32	2.20 ± 0.44	2.52 ± 0.68	<.001
Tbil (mmol/L)	11.67 ± 5.16	13.13 ± 5.91	10.92 ± 4.87	11.83 ± 5.07	.164
Urea (mmol/L)	5.44 ± 1.39	5.49 ± 1.65	5.51 ± 1.50	5.52 ± 1.66	.956
TG (mmol/L)	1.62 ± 1.02	1.94 ± 1.33	2.09 ± 1.37	2.05 ± 1.42	.002
TC (mmol/L)	3.83 ± 1.07	3.95 ± 1.02	3.73 ± 1.27	3.85 ± 1.03	.783
LDL-C (mmol/L)	2.53 ± 0.90	2.67 ± 0.89	2.46 ± 1.02	2.60 ± 0.84	.577
HDL-C (mmol/L)	1.00 ± 0.27	0.93 ± 0.26	0.88 ± 0.25	0.94 ± 0.25	.007
Kazahk patients
HbAlc (%)	2.17 ± 0.33	2.16 ± 0.27	2.3 ± 0.28	2.51 ± 0.59	<.001
Tbil (mmol/L)	13.52 ± 5.94	11.81 ± 5.49	14.03 ± 6.81	12.41 ± 6.64	.152
Urea (mmol/L)	5.53 ± 1.47	5.67 ± 1.49	5.63 ± 1.47	5.48 ± 1.56	.873
TG (mmol/L)	1.67 ± 1.60	1.85 ± 1.21	2.08 ± 1.34	2.23 ± 1.51	.026
TC (mmol/L)	4.02 ± 0.95	4.15 ± 0.88	4.15 ± 0.92	3.81 ± 0.82	.127
LDL-C (mmol/L)	2.59 ± 0.80	2.71 ± 0.81	2.66 ± 0.86	2.35 ± 0.74	.040
HDL-C (mmol/L)	1.13 ± 0.30	1.00 ± 0.31	1.07 ± 0.29	0.99 ± 0.29	<.001

Figure 1. The Gensini scores in different ethnic groups classified by the serum FPG. P < .001 compared to normal individuals (FPG < 5.6 mmol/L).

Figure 2. The correlation between serum FPG and Gensini scores in different ethnic groups estimated by Pearson analysis.

Table 3. Logistic regression analysis the risk of CAD.

	All patients		Han patients		Uyghur patients		Kazahk patients
Predictors	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P
Age, years	1.07 (1.05–1.08)	<.001	1.06 (1.04–1.09)	<.001	1.08 (1.06–1.11)	<.001	1.05 (1.02–1.08)	<.001
Male sex	0.65 (0.46–0.9)	.011	0.72 (0.41–1.27)	.261	0.48 (0.27–0.86)	.013	0.69 (0.36–1.33)	.267
Smoking	2.67 (1.96–3.65)	<.001	2.5 (1.45–4.28)	.001	2.98 (1.72–5.17)	<.001	2.89 (1.63–5.12)	<.001
Hypertension	1.6 (1.24–2.07)	<.001	1.87 (1.22–2.85)	.004	1.33 (0.84–2.1)	.021	1.67 (1.04–2.68)	.032
FPG (mmol/L)	1.27 (1.17–1.38)	<.001	1.22 (1.07–1.39)	.003	1.21 (1.08–1.37)	.002	1.53 (1.25–1.87)	<.001
HbAlc (%)	1.01 (0.73–1.41)	.931	0.91 (0.57–1.45)	.682	0.96 (0.49–1.86)	.904	1.07 (0.52–2.19)	.850
TC (mmol/L)	0.88 (0.64–1.2)	.423	1.29 (0.74–2.23)	.367	0.66 (0.38–1.15)	.144	0.86 (0.48–1.53)	.604
LDL-C (mmol/L)	0.98 (0.69–1.4)	.918	0.71 (0.38–1.32)	.282	1.25 (0.65–2.4)	.499	1.06 (0.56–2.02)	.859
HDL-C (mmol/L)	0.72 (0.45–1.13)	.152	0.52 (0.25–1.1)	.088	1.05 (0.43–2.57)	.910	0.98 (0.43–2.26)	.965

Data availability statement

Due to the nature of this research, participants of this study did not agree for their data to be shared publicly, so supporting data is not available.