Long-term effects of home-based pulmonary rehabilitation on idiopathic interstitial pneumonia patients

Figures & data

Figure 1. Flow diagram of patient disposition.

Table 1. Baseline characteristics in ILD patients.

Variable	Control group (n = 30)	Home-based rehabilitation group (n = 30)	P
Demographic characteristics
Age, year	56.7 ± 6.3	55.9 ± 7.2	0.649
Gender, n (%)			0.796
Male	15 (50.0)	14 (46.7)
Female	15 (50.0)	16 (53.3)
BMI, kg/m^2	26.5 ± 5.1	26.9 ± 6.3	0.788
Smoker, n (%)	7 (23.3)	9 (30)	0.559
Clinical characteristics
FEV1, % predicted	65.3 ± 9.1	64.3 ± 9.9	0.685
FVC, % predicted	73.2 ± 13.2	72.8 ± 8.3	0.889
DLCO,% predicted	43.7 ± 11.9	44.2 ± 12.3	0.873
6MWD, m	333.6 ± 91.2	348.5 ± 106.1	0.562
mMRC	2.7 ± 0.9	2.9 ± 1.1	0.444
SGRQ (total score)	46.1 ± 18.7	48.1 ± 20.3	0.696

ILD: interstitial lung disease; BMI: body mass index; FEV1: forced expiratory volume in 1 sec; FVC: forced vital capacity; DLCO: diffusion capacity of carbon monoxide; 6MWD: 6-min walk distance; mMRC: Modified Medical Research Council; SGRQ: St George’s Respiratory Questionnaire.

Figure 2. Changes in the outcome measures in the control and home-based PR groups over the duration of study (a) mMRC, (b) 6MWD, and (c) SGRQ.

Table 2. Changes of pulmonary function and other measures at baseline, 12 weeks, and 12 months.

	Control group (n = 30)				Home-based PR group (n = 30)				P value (control vs home-based PR)
Variable	Baseline	12 weeks	12 months	Global P value	Baseline	12 weeks	12 months	Global P value	Baseline	12 weeks	12 months
FEV1, % predicted	65.3 ± 9.1	65.8 ± 9.0	67.9 ± 8.3	0.252	64.3 ± 9.9	71.3 ± 8.9*	72.8 ± 9.2***^, ^#	0.003	0.685	0.021	0.034
FVC, % predicted	73.2 ± 13.2	74.2 ± 9.9	78.2 ± 12.9	0.143	72.8 ± 8.3	79.4 ± 8.8**	85.1 ± 10.6***^, ^###	0.001	0.889	0.036	0.027
DLCO, % predicted	43.7 ± 11.9	44.5 ± 9.1	47.2 ± 7.5	0.178	44.2 ± 12.3	49.8 ± 10.2*	52.3 ± 9.1*^, ^#	0.005	0.873	0.038	0.021
6MWD,m	333.6 ± 91.2	345.9 ± 76.5	361.2 ± 88.7	0.239	348.5 ± 106.1	403.6 ± 100.3***	443.8 ± 96.5*^, ^##	0.001	0.562	0.015	0.001
mMRC	2.7 ± 0.9	2.5 ± 0.6	2.4 ± 0.8	0.178	2.9 ± 1.1	2.2 ± 0.9**	1.9 ± 0.8*^, ^#	0.001	0.444	0.134	0.019
SGRQ (total score)	46.1 ± 18.7	45.2 ± 15.9	42.6 ± 16.8	0.449	48.1 ± 20.3	30.8 ± 16.7*	29.1 ± 15.2*	0.001	0.696	0.001	0.002

*P < 0.05, **P < 0.01, ***P < 0.001, significant difference from baseline in the control group and home-based group, respectively.

^# P < 0.05, ^##P < 0.01, ^###P < 0.001, significant difference from 12 weeks in the control group and home-based group, respectively.

FEV1: forced expiratory volume in 1 sec; FVC: forced vital capacity; DLCO: diffusion capacity of carbon monoxide; 6MWD: 6-min walk distance; mMRC: modified Medical Research Council; SGRQ: St George’s Respiratory Questionnaire.

Data availability statement

Due to the nature of this research, participants of this study did not agree for their data to be shared publicly, so supporting data is not available.