Antiallodynic and anti-hyperalgesia effects of Tiliacora triandra against cisplatin-induced peripheral neuropathy

Figures & data

Table 1. Effect of TTE on body weight and haematological indices in CISP-treated rats.

Parameters	Normal control	CISP control	TTE250+CISP	TTE500+CISP
Body weight (g)	426.66 ± 20.89	238.33 ± 29.77*	315.83 ± 42.94**	285 ± 35.77**
Haemoglobin	15.93 ± 0.68	10.86 ± 2.60*	13.36 ± 1.50	12.55 ± 2.53
WBC (×10^3/mm^3)	3.67 ± 2.09	2.32 ± 1.01*	3.11 ± 0.45**	3.78 ± 2.40**
RBC (×10^6/mm^3)	8.73 ± 0.40	5.04 ± 1.03*	7.14 ± 0.73**	6.57 ± 1.09**
Platelet count (×10^3/mm^3)	883.66 ± 167.77	588.66 ± 157.64*	765.33 ± 137.87**	765.66 ± 123.76**

Values are expressed as means ± SD (n = 6). The data were statistically analysed by one-way ANOVA followed by Bonferroni multiple comparison test.

*P < 0.05 as compared to normal control.

**P < 0.05 as compared to CISP control

Figure 1. Effect of oral administration of TTE on thermal hyperalgesia in cisplatin-treated rats. (A) Hot plate test, (B) Tail immersion test. Values represents mean ± SD (n = 6). Data analysis was performed using one way ANOVA followed by Bonferroni post hoc analysis. *P < 0.05 compared to normal control group; **P < 0.05 compared to cisplatin alone treated group.

Figure 2. Effect of oral administration of TTE on mechanical allodynia in cisplatin-treated rats. Values represents mean ± SD (n = 6). Data analysis was performed using one way ANOVA followed by Bonferroni post hoc analysis. *P < 0.05 compared to normal control group; **P < 0.05 compared to cisplatin alone treated group.

Figure 3. Effect of oral administration of TTE on nociception in cisplatin-treated rats. (A) First phase of formalin induced paw licking, (B) Second phase of formalin induced paw licking, (C) Acetic acid induced writhing. Values represents mean ± SD (n = 6). Data analysis was performed using one way ANOVA followed by Bonferroni post hoc analysis. *P < 0.05 compared to normal control group; **P < 0.05 compared to cisplatin alone treated group.

Figure 4. Effect of oral administration of TTE on rotarod performance in cisplatin-treated rats. Values represents mean ± SD (n = 6). Data analysis was performed using one way ANOVA followed by Bonferroni post hoc analysis. *P < 0.05 compared to normal control group; **P < 0.05 compared to cisplatin alone treated group.

Data availability statement

Due to the nature of this research, participants of this study did not agree for their data to be shared publicly, as such the supporting data associated with this study is not publicly available.