Biological functions and molecular mechanisms of LINC00961 in human cancer

Figures & data

Table 1. Functional characterization of lncRNA LINC00961 in the growth of cancers.

Type	Functions	Roles	Refs
HCC	Proliferation, colony formation, cell cycle, apoptosis	Anti-oncogene	Yin et al. 2019
LC	Proliferation, apoptosis	Anti-oncogene	Jiang et al. 2018; Sui et al. 2022
RCC	Proliferation, cell cycle, apoptosis, xenograft growth	Anti-oncogene	Chen et al. 2019
SM	Proliferation, apoptosis, xenograft growth	Anti-oncogene	Mu et al. 2019
OSCC	Proliferation, cell cycle, apoptosis, xenograft growth	Anti-oncogene	Pan et al. 2019
Glioma	Proliferation	Anti-oncogene	Lu et al. 2018
TSCC	Proliferation	Anti-oncogene	Zhang et al. 2019b

HCC, hepatocellular carcinoma; RCC, renal cell carcinoma; OSCC, oral squamous cell carcinoma; TSCC, tongue squamous cell carcinoma; LC, lung cancer; SM, skin melanoma; NA, not applicable.

Table 2. Functional characterization of lncRNA LINC00961 in the metastasis of cancers.

Type	Functions	Roles	Refs
HCC	Invasion, metastasis	Anti-oncogene	Yin et al. 2019
LC	Invasion, metastasis, xenograft growth	Anti-oncogene	Huang et al. 2018; Sui et al. 2022
RCC	Invasion, metastasis, xenograft growth	Anti-oncogene	Chen et al., 2019
SM	Invasion, metastasis	Anti-oncogene	Mu et al. 2019
Glioma	Invasion, metastasis	Anti-oncogene	Lu et al. 2018
TSCC	Invasion	Anti-oncogene	Zhang et al. 2019b
CC	Invasion, metastasis	Anti-oncogene	Wu et al. 2020

HCC, hepatocellular carcinoma; RCC: renal cell carcinoma; OSCC, oral squamous cell carcinoma; TSCC, tongue squamous cell carcinoma; LC, lung cancer; SM, skin melanoma; CC, colon cancer; NA, not applicable.

Figure 1. The related mechanism of LINC00961-mediated cancer progression.

Table 3. Expression of lncRNA LINC00961 in various cancers and its clinical significance.

Type	Expression	Clinical roles of LINC00961 downregulation	Refs
HCC	Low	Tumor size, LNM, clinical stage, OS	Yin et al. 2019
LC	Low	Advanced stage, LNM, OS, DFS	Jiang and Huang et al. 2018; Chen et al. 2017
RCC	NA	OS (TCGA)	Chen et al. 2019
SM	Low	OS (TCGA)	Mu et al. 2019
OSCC	Low	NA	Pan et al. 2019
Glioma	Low	WHO grade, KPS score, OS	Lu et al. 2018
TSCC	Low	NA	Zhang et al. 2019b
CC	Low	NA	Wu et al. 2020
BC	Low	Smoking status, age of menarche	Mehrpour et al. 2020

HCC, hepatocellular carcinoma; RCC, renal cell carcinoma; OSCC, oral squamous cell carcinoma; TSCC, tongue squamous cell carcinoma; CC, colon cancer; LC, lung cancer; SM, skin melanoma; BC, breast cancer; NA, not applicable; KPS, Karnofsky performance score; OS, overall survival; DFS, disease-free survival; LNM, lymph node metastasis; TCGA, The Cancer Genome Atlas.

Yin J, Liu Q, Chen C, Liu W. 2019. Small regulatory polypeptide of amino acid response negatively relates to poor prognosis and controls hepatocellular carcinoma progression via regulating microRNA-5581-3p/human cardiolipin synthase 1. J Cell Physiol. 234:17589–17599.

 PubMed Web of Science ®Google Scholar

Jiang B, Liu J, Zhang YH, Shen D, Liu S, Lin F, Su J, Lin QF, Yan S, Li Y, et al. 2018. Long noncoding RNA LINC00961 inhibits cell invasion and metastasis in human non-small cell lung cancer. Biomed Pharmacother. 97:1311–1318.

 PubMed Web of Science ®Google Scholar

Sui J, Zhao Q, Zhang Y, Liang G. 2022. Dysregulated LINC00961 Contributes to the Vitality and Migration of NSCLC Via miR-19a-3p/miR-19b-3p/miR-125b-5p. DNA Cell Biol. 41(3):319–329.

 PubMed Web of Science ®Google Scholar

Chen D, Zhu M, Su H, Chen J, Xu X, Cao C. 2019. LINC00961 restrains cancer progression via modulating epithelial-mesenchymal transition in renal cell carcinoma. J Cell Physiol. 234:7257–7265.

 PubMed Web of Science ®Google Scholar

Mu X, Mou KH, Ge R, Han D, Zhou Y, Wang LJ. 2019. Linc00961 inhibits the proliferation and invasion of skin melanoma by targeting the miR-367/PTEN axis. Int J Oncol. 55:708–720.

 PubMed Web of Science ®Google Scholar

Pan LN, Sun YR. 2019. LINC00961 suppresses cell proliferation and induces cell apoptosis in oral squamous cell carcinoma. Eur Rev Med Pharmacol Sci. 23:3358–3365.

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Lu XW, Xu N, Zheng YG, Li QX, Shi JS. 2018. Increased expression of long noncoding RNA LINC00961 suppresses glioma metastasis and correlates with favorable prognosis. Eur Rev Med Pharmacol Sci. 22:4917–4924.

 PubMed Web of Science ®Google Scholar

Zhang L, Shao L, Hu Y. 2019b. Long noncoding RNA LINC00961 inhibited cell proliferation and invasion through regulating the Wnt/β-catenin signaling pathway in tongue squamous cell carcinoma. J Cell Biochem. 120:12429–12435.

 PubMed Web of Science ®Google Scholar

Huang Z, Lei W, Tan J, Hu HB. 2018. Long noncoding RNA LINC00961 inhibits cell proliferation and induces cell apoptosis in human non-small cell lung cancer. J Cell Biochem. 119:9072–9080.

 PubMed Web of Science ®Google Scholar

Wu H, Dai Y, Zhang D, Zhang X, He Z, Xie X, Cai C. 2020. LINC00961 inhibits the migration and invasion of colon cancer cells by sponging miR-223-3p and targeting SOX11. Cancer Med. 9:2514–2523.

 PubMed Web of Science ®Google Scholar

Chen WJ, Tang RX, He RQ, Li DY, Liang L, Zeng JH, Hu XH, Ma J, Li SK, Chen G. 2017. Clinical roles of the aberrantly expressed lncRNAs in lung squamous cell carcinoma: a study based on RNA-sequencing and microarray data mining. Oncotarget. 8:61282–61304.

 PubMedGoogle Scholar

Mehrpour LS, Arabpour M, Esmaeili R, Esmaeili R, Naghizadeh MM, Tavakkoly Bazzaz J, Shakoori A. 2020. Evaluation of the potential role of long non-coding RNA LINC00961 in luminal breast cancer: a case-control and systems biology study. Cancer Cell Int. 20:478.

 PubMed Web of Science ®Google Scholar