Increased papillary microcirculation in inactive uveitis patients by optical coherence tomography angiography

Figures & data

Figure 1. RPCvd% and pRNFL thickness in modified Garway-Heath sectors in a normal subject. The Angio Disc radial peripapillary capillary (RPC) enface image was separated by modified Garway-Heath sector grid into 8 sectors by 2 circles with a diameter of 2㎜ and 4㎜. (a) En-face OCT image of the left eye, which is the scan of interest for capillary density measurement. (b) En-face angioflow RPC image of 8 sectors by 2 circles diameter around the ONH. c RPCvd% map. (d) pRNFL thickness map, arcuate regions look like butterfly wings because of warm color code with higher pRNFL thickness.

Table 1. Characteristics of the patients included in the study.

	Active uveitis
	Anterior Uveitis	Pan Uveitis	Inactive uveitis	Healthy control
Subjects (eyes)	23	17	12	21
Gender, male (ratio)	13 (56.5%)	6 (35.3%)	6 (50.0%)	13 (61.9%)
Age, years mean ± SD (range)	42.62 ± 11.51 (18-63)		40.67 ± 9.02 (18-56)	42.43 ± 12.99 (26-67)

Table 2. RPCvd% measurement in patients with active and inactive uveitis and healthy controls: comparison between groups and test post hoc results pairwise.

RPCvd (%)	Inactive Uveitis	Active Uveitis	Healthy Controls	Kruskal-Wallis test
T	55.83 ± 1.75	55.78 ± 2.88	56.57 ± 2.20	p = 0.490
S	53.83 ± 2.55	52.78 ± 4.75	55.10 ± 3.92	p = 0.156
N	50.00 ± 3.46	48.00(50.00-46.00)	49.43 ± 3.40	p = 0.148
I	57.50(59.00-55.25)	54.00(56.75-50.25)	55.81 ± 4.24	p = 0.015
Whole Image	51.48 ± 1.69	50.15(50.70-48.48)	51.40(51.90-48.85)	p = 0.028
Inside Disc	51.48 ± 3.71	49.70(51.75-46.20)	52.23 ± 5.07	p = 0.020
Peripapillary	53.78 ± 1.62	52.65(54.08-51.23)	53.44 ± 3.29	p = 0.173
Superior-Hemi	53.53 ± 1.88	52.40(54.30-51.10)	53.81 ± 3.04	p = 0.171
Inferior-Hemi	51.05 ± 1.64	52.70(54.20-50.08)	53.03 ± 3.75	p = 0.135
Nasal Superior	50.05 ± 3.75	47.73 ± 4.75	49.56 ± 3.57	p = 0.108
Nasal Inferior	51.50(52.48-46.98)	47.84 ± 4.09	48.11 ± 4.61	p = 0.340
Inferior Nasal	55.84 ± 2.97	51.55(53.70-47.73)	52.41 ± 5.85	p = 0.002
Inferior Tempo	58.41 ± 2.45	56.67 ± 5.25	58.67 ± 4.74	p = 0.398
Tempo Inferior	53.70 ± 2.74	54.72 ± 3.95	54.66 ± 3.19	p = 0.639
Tempo Superior	57.53 ± 2.00	56.72 ± 3.43	57.50 ± 3.23	p = 0.538
Superior Tempo	57.18 ± 2.64	55.48 ± 4.63	57.55 ± 4.41	p = 0.147
Superior Nasal	51.00 ± 3.34	50.15(54.68-48.00)	52.31 ± 4.82	p = 0.403
	I quadrant	Whole image	Inside Disc	IN sector
Inactive vs active	0.036	0.041		0.001
Active vs healthy			0.026

Table 3. pRNFL thickness measurement in patients with active and inactive uveitis and healthy controls: comparison between groups and test post hoc results pairwise.

pRNFL Thickness (um)	Inactive Uveitis	Active Uveitis	Healthy Controls	Kruskal-Wallis test
T	86.25 ± 11.07	87.00(98.00-79.25)	80.24 ± 1.056	p = 0.033
S	147.75 ± 16.87	152.00(178.75-135.25)	145.05 ± 15.31	p = 0.268
N	105.83 ± 17.66	111.00(130.75-98.25)	103.90 ± 17.95	p = 0.196
I	158.17 ± 14.78	159.50(179.25-142.25)	150.38 ± 16.21	p = 0.169
Peripapillary	123.00 ± 9.70	124.50(143.75-114.25)	117.00(121.00-112.00)	p = 0.080
Superior-Hemi	121.67 ± 10.51	124.00(143.25-112.25)	118.00(122.00-113.00)	p = 0.261
Inferior-Hemi	124.42 ± 9.44	127.00(138.75-114.25)	116.00(120.50-110.00)	p = 0.032
Nasal Superior	113.50 ± 16.26	117.00(135.75-103.25)	115.05 ± 20.73	p = 0.716
Nasal Inferior	94.92 ± 18.84	101.50(123.00-88.25)	90.33 ± 17.68	p = 0.035
Inferior Nasal	160.50(165.25-141.25)	145.50(176.00-133.00)	149.86 ± 24.86	p = 0.831
Inferior Tempo	167.00 ± 20.44	172.50(187.00-151.75)	153.76 ± 14.94	p = 0.024
Tempo Inferior	79.50(97.25-74.50)	87.00(100.75-78.25)	75.00(86.50-68.50)	p = 0.005
Tempo Superior	83.00(91.00-80.25)	87.00(96.50-81.25)	81.43 ± 11.72	p = 0.087
Superior Tempo	156.92 ± 18.75	146.00(164.25-132.25)	140.71 ± 17.73	p = 0.073
Superior Nasal	138.00 ± 17.67	157.00(191.50-129.00)	149.67 ± 25.53	p = 0.157
	T	IH	NI	IT	TI
Active vs healthy	0.009	0.010	0.011	0.019	0.001

Table 4. Differences in patients with anterior and pan uveitis in active phase.

pRNFL Thickness (um)	Anterior Uveitis	Pan Uveitis	Mann-Whitney test
Inferior-Hemi	121.00(133.00-113.00)	138.59 ± 32.12	p = 0.042
Nasal Inferior	94.00(111.00-81.00)	120.06 ± 34.27	p = 0.027
Tempo Superior	83.00(91.00-76.00)	95.00(114.50-85.00)	p = 0.004

Table 5. Correlation analysis between RPCvd% and pRNFL in active uveitis.

Sectors	RPCvd%	pRNFL um	Spearman test
S quadrant	52.78 ± 4.75	152.00 (178.75135.25)	r = 0.427, p = 0.006
N quadrant	48.00 (50.00-46.00)	111.00 (130.75-98.25)	r = 0.453, p = 0.003
Peripapillary	52.65 (54.08-51.23)	124.50 (143.75-114.25)	r = 0.394, p = 0.012
Superior-Hemi	52.40 (54.30-51.10)	124.00 (143.25-112.25)	r = 0.397, p = 0.016
Inferior-Hemi	52.70 (54.20-50.08)	127.00 (138.75-114.25)	r = 0.396, p = 0.011
Nasal Inferior	47.84 ± 4.09	101.50 (123.00-88.25)	r = 0.557, p = 0.000
Tempo Inferior	54.72 ± 3.95	87.00 (100.75-78.25)	r = 0.391, p = 0.013
Superior Tempo	55.48 ± 4.63	146.00 (164.25-132.25)	r = 0.324, p = 0.042
Superior Nasal	50.15 (54.68-48.00)	157.00 (191.50-129.00)	r = 0.481, p = 0.002

Table 6. Correlation analysis between RPCvd% and pRNFL in inactive uveitis.

Sectors	RPCvd%	pRNFL um	Spearman test
T quadrant	55.83 ± 1.75	86.25 ± 11.07	r = 0.697, p = 0.012*
S quadrant	53.83 ± 2.55	147.75 ± 16.87	r = 0.755, p = 0.005*
N quadrant	50.00 ± 3.46	105.83 ± 17.66	r = 0.688, p = 0.013*
Peripapillary	53.78 ± 1.62	123.00 ± 9.70	r = 0.687, p = 0.014*
Superior-Hemi	53.53 ± 1.88	121.67 ± 10.51	r = 0.725, p = 0.008*
Inferior-Hemi	51.05 ± 1.64	124.42 ± 9.44	r = 0.595, p = 0.041*
Nasal Superior	50.05 ± 3.75	113.50 ± 16.26	r = 0.669, p = 0.017
Nasal Inferior	51.50(52.48-46.98)	94.92 ± 18.84	r = 0.825, p = 0.001
Inferior Nasal	55.84 ± 2.97	160.50(165.25-141.25)	r = 0.674, p = 0.016
Tempo Inferior	53.70 ± 2.74	79.50(97.25-74.50)	r = 0.632, p = 0.028
Tempo Superior	57.53 ± 2.00	83.00(91.00-80.25)	r = 0.759, p = 0.004
Superior Tempo	57.18 ± 2.64	156.92 ± 18.75	r = 0.712 p = 0.009*
Superior Nasal	51.00 ± 3.34	138.00 ± 17.67	r = 0.604, p = 0.038*

*Pearson test.