Associations between genetically predicted plasma N-glycans and pancreatic cancer risk

Figures & data

Figure 1. Study design flow chart.

Figure 2. Associations between genetically predicted levels of IGP glycans and pancreatic cancer risk.

Figure 3. Associations of predicted PGP glycan levels and risk of pancreatic cancer.

Figure 4. The structure of pancreatic cancer associated PGP110.

Table 1. Associations between genetically predicted plasma N-glycan levels and pancreatic cancer risk.

Trait	OR (95% CI)^a	P value^b
PGP110	0.57 (0.45–0.74)	1.92×10^−5
IGP59	1.21 (1.05–1.38)	6.26×10^−3
IGP19	0.58 (0.38–0.88)	0.01
IGP02	0.86 (0.75–0.98)	0.02
IGP34	1.32 (1.04–1.66)	0.02
IGP42	0.86 (0.75–0.98)	0.02
IGP58	1.18 (1.03–1.35)	0.02
IGP60	1.18 (1.03–1.36)	0.02
IGP77	0.78 (0.64–0.95)	0.02
IGP61	1.18 (1.02–1.37)	0.03
PGP34	1.15 (1.01–1.32)	0.04
IGP22	0.84 (0.71–0.99)	0.04
IGP03	1.40 (0.98–1.99)	0.06
IGP09	0.87 (0.75–1.01)	0.06
IGP43	1.43 (0.98–2.09)	0.06
IGP49	0.87 (0.75–1.01)	0.06
IGP06	0.87 (0.76–1.01)	0.07
IGP46	0.87 (0.76–1.01)	0.07
IGP63	1.13 (0.99–1.29)	0.08
IGP30	0.84 (0.69–1.03)	0.09
IGP64	1.12 (0.97–1.28)	0.11
IGP68	0.89 (0.77–1.03)	0.11
IGP18	1.28 (0.94–1.74)	0.12
PGP56	1.11 (0.97–1.28)	0.13
PGP57	1.11 (0.97–1.28)	0.13
IGP39	1.08 (0.97–1.21)	0.15
IGP45	1.15 (0.95–1.40)	0.15
IGP17	0.89 (0.76–1.05)	0.16
IGP40	1.08 (0.97–1.21)	0.16
IGP26	0.91 (0.8–1.04)	0.17
IGP05	1.15 (0.94–1.42)	0.18
IGP51	0.88 (0.73–1.07)	0.19
IGP53	0.88 (0.73–1.07)	0.20
PGP59	0.87 (0.7–1.09)	0.23
PGP70	0.86 (0.66–1.1)	0.23
PGP79	1.17 (0.9–1.53)	0.23
IGP57	0.88 (0.72–1.08)	0.23
PGP67	1.10 (0.93–1.30)	0.25
IGP12	0.88 (0.72–1.09)	0.25
PGP30	0.94 (0.84–1.05)	0.26
PGP72	1.12 (0.92–1.37)	0.26
IGP62	1.09 (0.94–1.26)	0.26
IGP66	0.92 (0.8–1.06)	0.26
IGP70	0.92 (0.8–1.06)	0.26
IGP71	0.92 (0.8–1.06)	0.26
IGP55	0.83 (0.59–1.16)	0.27
PGP25	1.08 (0.93–1.26)	0.29
IGP13	0.91 (0.77–1.09)	0.30
PGP02	0.91 (0.77–1.09)	0.31
PGP60	0.92 (0.78–1.08)	0.31
IGP11	0.92 (0.77–1.09)	0.33
IGP69	1.07 (0.93–1.24)	0.33
PGP109	1.14 (0.87–1.48)	0.34
PGP63	0.93 (0.79–1.08)	0.34
PGP80	0.93 (0.79–1.09)	0.34
IGP67	1.07 (0.93–1.22)	0.34
IGP72	1.07 (0.93–1.23)	0.34
PGP74	1.08 (0.92–1.28)	0.35
IGP48	0.83 (0.57–1.22)	0.35
IGP74	1.07 (0.93–1.23)	0.35
PGP47	1.08 (0.92–1.27)	0.37
IGP75	1.06 (0.93–1.22)	0.37
PGP18	0.90 (0.72–1.14)	0.38
PGP43	0.92 (0.77–1.11)	0.39
IGP76	0.94 (0.81–1.09)	0.41
IGP10	0.91 (0.73–1.15)	0.44
IGP50	0.92 (0.73–1.14)	0.44
PGP99	0.89 (0.65–1.21)	0.45
IGP14	0.94 (0.81–1.1)	0.46
IGP31	1.06 (0.9–1.25)	0.48
PGP06	0.93 (0.75–1.15)	0.49
PGP107	0.93 (0.75–1.15)	0.49
PGP38	1.09 (0.86–1.37)	0.49
PGP40	1.09 (0.86–1.37)	0.49
PGP45	1.11 (0.82–1.51)	0.49
PGP61	1.09 (0.85–1.39)	0.49
PGP78	1.07 (0.88–1.30)	0.49
PGP82	0.94 (0.78–1.13)	0.49
PGP83	0.92 (0.72–1.17)	0.49
PGP84	0.92 (0.72–1.17)	0.49
PGP85	0.92 (0.73–1.17)	0.49
PGP86	1.08 (0.86–1.36)	0.49
PGP88	0.92 (0.73–1.16)	0.49
PGP89	0.92 (0.73–1.16)	0.49
PGP90	1.08 (0.87–1.35)	0.49
IGP24	0.97 (0.87–1.07)	0.49
PGP87	0.92 (0.73–1.17)	0.50
PGP15	2.13×10^−5 (9.34×10^−20–24.84×10^9)	0.52
IGP47	1.09 (0.84–1.42)	0.52
IGP36	1.06 (0.87–1.29)	0.57
PGP22	1.05 (0.89–1.24)	0.58
IGP52	0.95 (0.78–1.16)	0.62
PGP20	0.98 (0.88–1.08)	0.64
PGP33	1.06 (0.82–1.37)	0.64
IGP16	0.94 (0.74–1.21)	0.65
IGP32	1.03 (0.91–1.16)	0.65
IGP73	0.96 (0.78–1.17)	0.66
IGP08	1.05 (0.84–1.31)	0.67
IGP23	1.04 (0.85–1.28)	0.68
IGP25	1.09 (0.73–1.62)	0.68
IGP27	1.10 (0.71–1.68)	0.68
PGP111	0.97 (0.84–1.13)	0.69
PGP31	0.96 (0.78–1.18)	0.69
PGP17	0.97 (0.85–1.12)	0.70
IGP21	0.95 (0.73–1.24)	0.70
PGP29	1.03 (0.87–1.22)	0.74
PGP92	0.96 (0.75–1.23)	0.74
IGP37	1.03 (0.88–1.20)	0.74
IGP65	0.98 (0.84–1.13)	0.75
PGP112	1.02 (0.89–1.18)	0.76
IGP38	1.02 (0.88–1.19)	0.76
IGP29	1.01 (0.94–1.09)	0.77
PGP23	0.98 (0.82–1.16)	0.78
IGP07	1.06 (0.71–1.58)	0.79
PGP28	0.98 (0.84–1.14)	0.80
PGP39	0.97 (0.75–1.24)	0.80
IGP15	0.99 (0.9–1.08)	0.83
PGP32	0.99 (0.86–1.14)	0.86
PGP37	0.98 (0.77–1.24)	0.86
PGP03	1.02 (0.82–1.26)	0.88
PGP102	1.02 (0.82–1.27)	0.89
PGP50	0.98 (0.72–1.33)	0.89
PGP51	0.98 (0.74–1.30)	0.89
PGP52	0.98 (0.76–1.26)	0.89
IGP54	0.99 (0.8–1.21)	0.89
IGP28	1.00 (0.91–1.11)	0.94
PGP103	1.00 (0.81–1.24)	0.99
PGP105	1.00 (0.81–1.23)	0.99
PGP106	1.00 (0.81–1.23)	0.99
PGP24	1.00 (0.88–1.14)	0.99
PGP27	1.00 (0.84–1.19)	0.99
PGP36	1.00 (0.74–1.36)	0.99
IGP35	1.00 (0.91–1.11)	0.99

^a OR represents odds ratio per one standard deviation increase in genetically predicted levels of N-glycan; CI represents confidence interval of the odds ratio.

^b P value: derived from association analyses of 8275 cases and 6723 controls.

Data availability statement

The pancreatic cancer genetic data analyzed in the current study are available in the database of Genotypes and Phenotypes (dbGaP) at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gap through dbGaP accession phs000206.v5.p3 and phs000648.v1.p1. The association results for all analyzed N-glycans are deposited to Zenodo and are publicly available (https://doi.org/10.5281/zenodo.6872744).