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Pharmacology & Pharmaceutics

The effects of Gastrodia elata on anxiety-like behavior in mice

Lan-Qiao Hea Zhejiang University of Technology, Hangzhou, People’s Republic of China;b Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, People’s Republic of ChinaORCID Iconhttps://orcid.org/0009-0007-8894-7619View further author information
ORCID Icon,
Jia-Yu Linb Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, People’s Republic of ChinaORCID Iconhttps://orcid.org/0009-0004-1889-8469View further author information
ORCID Icon,
Ming-Zhi Yub Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, People’s Republic of ChinaORCID Iconhttps://orcid.org/0009-0000-7308-6181View further author information
ORCID Icon,
Peng-Yu Fanb Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, People’s Republic of ChinaView further author information
,
Cen-Jie Heb Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, People’s Republic of ChinaORCID Iconhttps://orcid.org/0009-0005-2905-5907View further author information
ORCID Icon &
Ting-Ting Zhaob Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-2375-058XView further author information
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Article: 2373197 | Received 29 Sep 2023, Accepted 05 Jun 2024, Published online: 04 Jul 2024

Figures & data

Figure 1. Effects of GE on food intake (A) and body weight (B). Data are presented as mean ± S.D. (n = 8 per group). *p < 0.05 shows comparison with the control group, and #p < 0.05 shows comparison with the cEFS group.

Figure 1. Effects of GE on food intake (A) and body weight (B). Data are presented as mean ± S.D. (n = 8 per group). *p < 0.05 shows comparison with the control group, and #p < 0.05 shows comparison with the cEFS group.

Figure 2. Effects of GE on the EPM test. Effects of GE on time spent in open arms (A). Effects of GE on the number of entries in the open arms (B). Data are presented as mean ± S.D. (n = 8 per group). *p < 0.05 shows comparison with the control group, and #p < 0.05 shows comparison with the cEFS group.

Figure 2. Effects of GE on the EPM test. Effects of GE on time spent in open arms (A). Effects of GE on the number of entries in the open arms (B). Data are presented as mean ± S.D. (n = 8 per group). *p < 0.05 shows comparison with the control group, and #p < 0.05 shows comparison with the cEFS group.

Figure 3. Effect of GE on the distance traveled in OFT. Data are presented as mean ± S.D. (n = 8 per group). *p < 0.05 shows comparison with the control group, and #p < 0.05 shows comparison with the cEFS group.

Figure 3. Effect of GE on the distance traveled in OFT. Data are presented as mean ± S.D. (n = 8 per group). *p < 0.05 shows comparison with the control group, and #p < 0.05 shows comparison with the cEFS group.

Figure 4. Effects of GE on the dopamine and serotonin levels in the brain. Effects of GE on dopamine (A) and serotonin (B) levels in the brain. Data are presented as mean ± S.D. (n = 8 mice per group). *p < 0.05 shows comparison with the control group, and #p < 0.05 shows comparison with the cEFS group.

Figure 4. Effects of GE on the dopamine and serotonin levels in the brain. Effects of GE on dopamine (A) and serotonin (B) levels in the brain. Data are presented as mean ± S.D. (n = 8 mice per group). *p < 0.05 shows comparison with the control group, and #p < 0.05 shows comparison with the cEFS group.

Figure 5. Effects of GE on the serum CORT level. Data are presented as mean ± S.D. (n = 8 mice per group). *p < 0.05 shows comparison with the control group, and #p < 0.05 shows comparison with the cEFS group.

Figure 5. Effects of GE on the serum CORT level. Data are presented as mean ± S.D. (n = 8 mice per group). *p < 0.05 shows comparison with the control group, and #p < 0.05 shows comparison with the cEFS group.

Figure 6. Effects of GE on c-fos expression in the PVN region of brain. Immunohistochemical image of c-fos positive cells in the PVN region (20x). The arrow shows the c-fos positive cells (A). Statistical comparison of the number of c-fos positive cells in the PVN brain region in different groups (B). Data are presented as mean ± S.D. (n = 8 mice per group). *p < 0.05 shows comparison with the control group, and #p < 0.05 shows comparison with the cEFS group.

Figure 6. Effects of GE on c-fos expression in the PVN region of brain. Immunohistochemical image of c-fos positive cells in the PVN region (20x). The arrow shows the c-fos positive cells (A). Statistical comparison of the number of c-fos positive cells in the PVN brain region in different groups (B). Data are presented as mean ± S.D. (n = 8 mice per group). *p < 0.05 shows comparison with the control group, and #p < 0.05 shows comparison with the cEFS group.

Data availability statement

The data that support the findings of this study are openly available in figshare https://doi.org/10.6084/m9.figshare.24219004.v5.

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