An Insight into the Research Concerning Panax ginseng C. A. Meyer Polysaccharides: A Review

ABSTRACT

Ginseng (Panax ginseng C. A. Meyer) is known as a valuable traditional Chinese herb for tens of centuries. Previous pharmacological and phytochemical investigations indicate that polysaccharides are a main biologically active ginseng component that possesses different bioactivities such as antitumor, immunoregulation, antioxidation, hepatoprotection, and anti-inflammation. Work is needed to summarize the full aspects of these polysaccharides systematically to boost their further investigation and application. In this review, studies on the extraction, purification, characterization, and bioactivity are introduced in detail. Moreover, the structure–bioactivity relationship of ginseng polysaccharides is explored and discussed. The uronic acids richer in ginseng polysaccharides tend to have higher biological effect, and the α-(1→4)-GalpA and α-(1→4)-Galp in the main chain are essential for the anti-inflammatory and antiviral effects. We believe our work proposes a helpful bibliography for further innovation and promotes these natural products in functional food.

KEYWORDS:

• Bioactivity
• extraction
• ginseng
• polysaccharide
• structural characterization

Highlights

• Ginseng (Panax ginseng C. A. Meyer) is a well-known Chinese medicinal plant.

• Ginseng polysaccharide is one of the abundant groups and bioactive components.

• Structure and bioactivities of ginseng polysaccharides are highlighted.

• The exact structure–bioactivity relationship is explored and discussed.

Disclosure statement

The authors declare no conflict of interest.

Additional information

Funding

This work was supported by the National Natural Science Foundation of China [21502177]; Youth Talents Project of Henan Province [2020HYTP046]; the Higher Education School Young Backbone Teacher Training Program of Henan Province [2018GGJS093]; the Basic Research Plan of Higher Education School Key Scientific Research Project of Henan Province [19zx012]; Program for Science and Technology Innovation Talents in Universities of Henan Province [20HASTIT037].