51
Views
12
CrossRef citations to date
0
Altmetric
Original Articles

DETERMINATION OF CILAZAPRIL AND HYDROCHLOROTHIAZIDE IN PHARMACEUTICALS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY

, &
Pages 1153-1161 | Received 18 May 2000, Accepted 17 Jan 2001, Published online: 02 Feb 2007
 

Abstract

A high performance liquid chromatography method was developed for the specific determination of cilazapril (CZP), hydrochlorothiazide (HCT) binary mixtures in pharmaceutical dosage form. Active substances were seperated by gradient system in that mobile phase consists of methanol-phosphate buffer. As a mobile phase flow rate was 0.8 ml.min−1 and Lichrospher 100 RP-18e (5 μm, 250 × 4 mm) was used as a stationary phase. Detection was carried out using a UV detector at 254nm and trimethoprim (TM) as an internal standard. The detector response was linear in the range of 15–200 μg.mL−1 for CZP and 10–150 μg.mL−1 for HCT. The relative standard deviation for this method was determined to be 1.35 and 1.67% for CZP and HCT respectively.

Acknowledgments

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 768.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.