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ABSTRACT
A novel PVC membrane electrode, selective for the determination of the antihypertensive medication sodium nitroprusside (SNP) based on cetylpyridinium-nitroprusside ion pair association as an electroactive material is described. The electrode shows a linear response for nitroprusside (NP) ion over the concentration range of 3 × 10−5 –1 × 10−2 M with lower detection limit of 2 × 10−5 M at 25°C. The electrode possesses a Nernstian slope of −27.0 ± 1.0 mV/decade and a fast potential response of 45 s, which is almost constant over a pH range of 2.0–10.0. Selectivity coefficient data for some common ions show negligible interference. An average recovery of 99.7% with relative standard deviation of 0.76% has been achieved for the determination of SNP in Nipride. The electrode has been utilized as an end point indicator electrode for the determination of SNP using potentiometric titration.