Figures & data
Figure 1. Rat thoracic aortic ring reactivity to NE before and after a 6-hour incubation with LPS. Control vessel rings were similarly incubated but without LPS. LPS treatment shifted the NE dose-response curve to the right indicating depressed vessel ring reactivity. Values are mean±SD (N=5 each).
Figure 2. Effect of NO synthesis inhibition on NE dose responses of vessel rings treated with LPS for 6 hours. Treatment with L-NAME shifted the NE dose-response curve back toward the left. Values are mean±SD (N=6 each).
Figure 3. Effect of NO scavenging on NE dose responses of vessel rings treated with LPS for 6 hours. Treatment with Hb also shifted the NE dose-response curve back toward the left. Values are mean±SD (N=5 each).
Figure 4. Effect of combined NO synthesis inhibition and NO scavenging on NE dose responses of vessel rings treated with LPS for 6 hours. Treatment with both NAME and Hb shifted the NE dose-response curve back toward the left. Values are mean±SD (N=5 each).
Figure 5. Improved vascular reactivity of LPS treated vessel rings following treatment with Hb, NAME, or both. When compared with control vessel rings (LPS+buffer), vessel rings treated with Hb, NAME or Hb+NAME showed a significantly lower logEC50 values. Values are mean±SD (N=4-6 each). *P<0.05, **P<0.01 compared with control.
