ARTIFICIAL CELLS CONTAINING DETOXICANTS ^*

Figures & data

Figure 53. Artificial cells containing enzymes and Dowex-50W-12. (From Chang, 1966. Courtesy of the American Society for Artificial Internal Organs.)

Figure 54. Effects of activated charcoal in BHC-artificial cells and of free activated charcoal on the platelet level of arterial and shunt-effluent blood. (From Chang et al., 1968. Courtesy of the American Society for Artificial Internal Organs.)

Table 4. Effects of 2-Hour Hemoperfusion on Systemic Platelets and Leucocytes

Dogs	Platelets/mm^3		WBC/mm^3
	Initial	2 hr Hemoperfusion	Initial	2 hr Hemoperfusion
Control
1	141,000	129,000	16,700	21,000
2	198,000	209,000	10,800	22,000
3	128,000	131,000	8,360	15,000
4	183,000	201,000	10,000	10,400
ACAC Microencapsulated Activated Charcoal
5	310,000	301,000	23,000	26,000
6	260,000	250,000	13,000	11,800
7	383,000	334,000	11,500	13,970
8	345,000	295,000	12,900	9,900
9	108,000	125,000	2,900	2,800
10	317,000	245,000	5,100	6,000
11	260,250	201,000	8,000	7,100
12	211,000	179,000	6,800	9,900
13	157,000	123,000	4,850	3,900
14	294,000	218,000	19,000	13,000
15	305,000	249,000	11,000	14,000
16	106,000	106,000	3,300	2,500
Free Activated Charcoal
17	208,000	68,000	11,700	3,200
18	130,000	78,000	6,900	2,800
19	169,000	92,000	6,600	1,500
20	273,000	119,000	8,700	3,980

From Chang and Malave (1970). Courtesy of American Society of Artificial Internal Organs.

Figure 55. Arterial pentobarbital level in dogs. Control: dog without treatment. Treated: dog with systematic circulation connected to an extracorporeal shunt containing 300 gm of ACAC artificial cells (blood flow 200 ml/mg) for two hours.

Figure 56. Arterial salicylate levels in dogs. Control: dog without treatment. Treated: dog with systematic circulation connected to an extracorporeal shunt containing 300 gm of ACAC artificial cells (blood flow 200 ml/min) for two hours.