Artificial Liver Support in the Third Millennium

Figures & data

Figure 1. Schematic drawing of the extracorporeal circuit indicating the plasmaferesis device and the BAL perfusion unit.

Table 1. Bioartificial liver support in large animals with acute liver failure

Author	Exp model, number of animals	Hybrid bioartificial system	Hepatocytes, number of cells	Survival ((hrs)) treated versus controls
Uchino et al., (([1998]))	Anhepatic dog n == 4	Collagen coated glassplates	Canine 6 billions	T: 55 ± 10.3 C: 21.3 ± 5.6
((Kelly et al., [1992]))	Anhepatic dog n == 3	Hollow fibre	C3A human 200 gram	not studied
Rozga et al., (([1993]))	Dog, liver ischemia n == 7	Hollow fibre microcarrier attached, charcoal column	porcine 6 billion	not studied
Sielaff, et al., (([1995]))	Dog, galactosamine n == 5	hollow fibre	porcine 6 billion	T: 47 hrs C: 36 hrs
Jauregui et al., (([1995]))	Rabbit, galactosamine n == 11	hollow fibre	rabbit 560 million	T: 4 out of 11 C: 1 out of 9
Gerlach, (([1996]))	Pig, anhepatic n == 9	hollow fibre		not studied
Sheil et al., (([1998]))	Pig, liver ischemia n == 5	hollow fibre		not studied
Flendrig et al., (([1999b]))	Pig, liver ischemia n == 8	non woven matrix	10–14 billions	T: 51 ± 3 C: 33 ± 3
Naruse et al., (([1998]))	Pig liver ischemia n == 4	non woven matrix	10 billions	T == 35.7 ± 2.6 C == 28.5 ± 2.6

Table 2. Clinical results of BAL treatments

	Number of patients
Uncontrolled studies ((phase 1))
Sussman et al, (([1994]))	11
Watanabe et al, (([1997]))	26
Kardassis et al, (([1999]))	8
Patzer et al, (([2000]))	4
Donini et al, (([2000]))	1
Chamuleau et al ((unpublished))	3
Controlled study
Ellis et al, (([1996]))	12 out of 24

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