The Toxicological Study of CCNU Controlled Release Film In Vivo

Figures & data

Table 1. Effects of CCNU film on blood corpuscles of mice (X ± SD)

Group	WBC/10^9 L^−1	RBC/10^12 L^−1	HGB/g L^−1	PLT/10^11 L^−1
CCNU 150 µg	8.77±2.41a	9.12±3.04	177.2±29a	1,291±337a
300 µg	8.29±1.97a	8.70±3.41	160.7±34a	1,244±239a
600 µg	7.90±2.21a	8.20±2.91	142.9±31b	1,114±310
1,200 µg	5.21±2.90	7.31±1.71	129.7±39	1,047±264
800 µg P.O.	3.80±1.70	6.92±2.44	109.0±33	894±276

Compared with P.O. group.

^aP < 0.01.

^bP < 0.05.

Figure 1. (a) Effects of CCNU P.O. on nerve cells of mice. (b) Effects of CCNU film on nerve cells of mice.