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Clinical and Experimental Hypertension Volume 26, 2004 - Issue 7-8
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Original

Hypertension and Heart Failure: Role of Neurohormonal Mechanisms

Massimo Volpe Chair and Division of Cardiology, 2nd Faculty of Medicine, University of Rome “La Sapienza,” Sant'Andrea Hospital, Via di Grottarossa, 1035‐9, Rome, 00189, Italy; IRCCS Neuromed, Pozzilli (IS), Italy
,
E. Pagannone Chair and Division of Cardiology, 2nd Faculty of Medicine, University of Rome “La Sapienza,” Sant'Andrea Hospital, Via di Grottarossa, 1035‐9, Rome, 00189, Italy
,
G. Tocci Chair and Division of Cardiology, 2nd Faculty of Medicine, University of Rome “La Sapienza,” Sant'Andrea Hospital, Via di Grottarossa, 1035‐9, Rome, 00189, Italy
&
S. Rubattu Chair and Division of Cardiology, 2nd Faculty of Medicine, University of Rome “La Sapienza,” Sant'Andrea Hospital, Via di Grottarossa, 1035‐9, Rome, 00189, Italy; IRCCS Neuromed, Pozzilli (IS), Italy
Pages 603-610 | Published online: 18 Nov 2004
 
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Abstract

Hypertension represents the most common associated cause of heart failure, and it is frequently involved in the pathogenesis of left ventricular dysfunction and its progression towards congestive heart failure. A common pathophysiological link of hypertension to heart failure is represented by the abnormalities of the neurohormonal profile and its impact on cardiac function, systemic hemodynamics and salt/water balance. This article synthetically reviews this aspect together with a specific analysis of the significance of measurements of neurohormones for diagnosis and prognostic stratification in heart failure.

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