Microstructure of Dispersed Colloidal Particles of a Bilayer Cubic Phase

Abstract

The microstructures of the interior phase of the cubic particles have been studied by dispersing the cubic phase formed by monoolein into different solvents. Steady‐state fluorescence probe techniques have been utilized to study the micropolarity changes of the cubic particles in different solvents, and to obtain fluorescence quenching for lissamine rhodamine B incorporated into the cubic particles by diacyl phosphatidylethanolamine (NBD‐PE) aqueous solution. It is found that the solvents inside and outside the cubic particles can be exchanged during the formation of the particles and the results of fluorescence quenching experiment also suggest that there might be two different water compartments extant inside the particles.

Keywords:

• Colloidal particles
• Cubic phase
• Drug delivery system

Acknowledgment

L.‐Q. Zheng is grateful for financial support from KIST‐EP 2000. This work was partly supported by the Natural Sciences Fund Foundation of China (Grant No. 20243005) of the Natural Sciences Fund Foundation of China.