Spectrophotometric Study of the Interaction of β‐Cyclodextrin with Hydroxamic acids

Abstract

Cyclodextrins have attracted considerable interest because of their ability to form stable inclusion complexes with a wide variety of inorganic and organic guest molecules. In the present communication, binding constant of β‐cyclodextrin and a series of substituted benzohydroxamic acids (X‐C₆H₄CON(OH)H), X=H, 4‐NO₂, 4‐Me 4‐OMe, and 2‐OH and N‐phenylbenzohydroxamic acid (C₆H₅CON(OH)C₆H₅) were determined at 27°C spectrophotometrically. In all the cases the formation of 1:1 host‐guest complex was established. The addition of β‐CD results in an increase in the absorbance intensity but does not cause a shift in λ_max. The values of binding constants are in good agreement with in those determined from kinetic and pH metric techniques.

Keywords:

• β‐CD‐hydroxamic acid
• inclusion complex
• binding constant
• intermolecular forces
• physicochemical properties

Acknowledgment

Grateful acknowledgment is made to Pt. Ravishankar Shukla University, Raipur for financial support in the form of UGC minor research project. The authors are also grateful to Prof. G. L. Mundhara, Head, SOS in Chemistry. Pt. Ravishankar Shukla University, Raipur, for providing laboratory facilities.