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Hemoglobin
international journal for hemoglobin research
Volume 27, 2003 - Issue 4
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Original Article

Production of Murine Monoclonal Antibody to Fetal Hemoglobin

Yegneshwar S. Iyer Institute of Immunohaematology, Indian Council of Medical Research (ICMR), 13th Floor, New Multistoreyed Building, King Edward Memorial Hospital Campus, Parel, Mumbai, 400 012, India
,
Manisha Patwardhan Institute of Immunohaematology, Indian Council of Medical Research (ICMR), 13th Floor, New Multistoreyed Building, King Edward Memorial Hospital Campus, Parel, Mumbai, 400 012, India
,
Vaishali Pujari Institute of Immunohaematology, Indian Council of Medical Research (ICMR), 13th Floor, New Multistoreyed Building, King Edward Memorial Hospital Campus, Parel, Mumbai, 400 012, India
,
Gayatri Shinde Institute of Immunohaematology, Indian Council of Medical Research (ICMR), 13th Floor, New Multistoreyed Building, King Edward Memorial Hospital Campus, Parel, Mumbai, 400 012, India
,
Paritosh Keertikar Institute of Immunohaematology, Indian Council of Medical Research (ICMR), 13th Floor, New Multistoreyed Building, King Edward Memorial Hospital Campus, Parel, Mumbai, 400 012, India
,
Swati Kulkarni Institute of Immunohaematology, Indian Council of Medical Research (ICMR), 13th Floor, New Multistoreyed Building, King Edward Memorial Hospital Campus, Parel, Mumbai, 400 012, India
,
Roshan B. Colah Institute of Immunohaematology, Indian Council of Medical Research (ICMR), 13th Floor, New Multistoreyed Building, King Edward Memorial Hospital Campus, Parel, Mumbai, 400 012, India
&
Dr. Dipika Mohanty Institute of Immunohaematology, Indian Council of Medical Research (ICMR), 13th Floor, New Multistoreyed Building, King Edward Memorial Hospital Campus, Parel, Mumbai, 400 012, India
 show all
Pages 229-234 | Received 06 Jun 2003, Accepted 01 Jul 2003, Published online: 07 Jul 2009
 
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Abstract

Fetal hemoglobin (Hb F) is a major hemoglobin (Hb) component at birth. Hb F levels are markedly elevated in a number of inherited and acquired disorders. Measurement of Hb F levels is usually carried out by alkali denaturation which is not very accurate for low and high values. An accurate estimation of Hb F, and also of F cells, is desired in many hematological disorders like sickle cell disease, in monitoring the efficacy of hydroxyurea (HU) therapy, to assess feto‐maternal hemorrhage (FMH) during pregnancy and in the postpartum period. We have raised a murine monoclonal antibody to human Hb F, that accurately measures the number of F cells by flow cytometry. The antibody was found to be potent and specific for F cells.

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