Serum Cystatin C and β₂-Microglobulin as Markers of Glomerular Filtration Rate

Figures & data

Figure 1. Correlation between creatinine clearance and 1/CyC and creatinine clearance and 1/β₂-MG as well as CyC and β₂-MG in all examined patients.

Table 1. Creatinine clearance, serum level of cystatin C, β₂-microglobulin and their correlations in groups of patients formed according to sex and age

Patients	No.	Ccr (mL/min)	CyC (mg/L)	β2-MG (mg/L)	Ccr vs. 1/CyC	Ccr vs. 1/β2-MG	CyC vs. β2-MG
Males	34	33.6±26.5	2.75±1.61a	7.78±6.88a	r = 0.825	r = 0.852	r = 0.882
					p<0.001	p<0.001	p<0.001
Females	41	43.6±26.7	1.88±0.98	4.12±2.86	r = 0.792	r = 0.761	r = 0.900
					p<0.001	p<0.001	p<0.001
<60 yrs	64	38.9±27.4	2.32±1.40	5.81±5.46	r = 0.816	r = 0.800	r = 0.884
					p<0.001	p<0.001	p<0.001
>60 yrs	11	40.0±24.9	2.01±1.18	5.60±5.10	r = 0.775	r = 0.809	r = 0.950
					p<0.001	p<0.001	p<0.001

Legend: No., number; yrs, years; Ccr, creatinine clearance; CyC, Cystatin C; β₂-MG, β₂-microglobulin.

^ap<0.025.

Figure 2. Correlation between creatinine clearance and 1/CyC and creatinine clearance and 1/β₂-MG in patients with different renal function (first row: Ccr<25 mL/min; second row: Ccr 25–60 mL/min; third row: Ccr>60 mL/min).

Figure 3. Correlation between creatinine clearance and 1/CyC and creatinine clearance and 1/β₂-MG in patient groups formed according to the primary renal diseases (first row: pts with glomerulonephritis without nephrotic proteinuria; second row; patients with glomerulonephritis with nephrotic proteinuria; third row: patients with pyelonephritis; fourth row: renal transplant patients).