Evolution of Total Antioxidant Status in a Model of Acute Renal Insufficiency in Rats

Figures & data

Figure 1. The administration of glycerol injection in groups 1 and 2 induced rhabdomyolysis with severe increase of serum creatine-kinase (CK). The levels of CK in the group 2 were significantly lower than those of the group 1 (p<0.001). The CK in the groups 1 and 2 were significantly higher than those of the groups control (3 and 4) (p<0.0001).

Figure 2. Serum urea (top panel) and serum creatinine (bottom panel) values in four groups. In groups 1 and 2 the glycerol injection induced severe acute renal failure (ARF) serum urea in groups 1 and 2 were higher than in groups control: 3 and 4 (p<0.0001), and urea were higher in group 2 than in group 1 (p<0,001). Serum creatinine in groups 1 and 2 were higher than in groups control: 3 and 4 (p<0.0001), and creatinine were higher in group 2 than in group 1 (p<0.001).

Figure 3. Total antioxidant status levels in group 1 was lower than in groups 2, 3, and 4 (p<0.005).

Table 1. General animal and laboratory data

	Group 1 (n = 7)	Group 2 (n = 7)	Group 3 (n = 7)	Group 4 (n = 7)
Body weight (g)	255±32	249±14	258±50	250±25
Creatine-kinase (U/L)	118,849±27,568a	1,279±1,011ab	77±16	80±15
Diuresis (mL/24)	2.0±1.5c	2.6±0.6c	11.6±1.0	12.3±0.6
Urea (mg/dL)	269±16a	586±147ab	21±3	22±6
Creatinine (mg/dL)	2.80±0.20a	5.8±0.78ab	0.73±0.12	0.68±0.11
TAS (mmol/L)	0.81±0.12d	1.34±0.11	1.27±0.35	1.27±0.30

^ap<0.0001 for the comparison with groups 3 and 4.

^bp<0.001 for the comparison with group 1.

^cp<0.001 for the comparison with groups 3 and 4.

^dp<0.005 for the comparison with groups 2, 3, and 4.