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CLINICAL STUDY

Increased Endothelin: Nitric Oxide Ratio Is Associated with Erythropoietin-Induced Hypertension in Hemodialysis Patients

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Pages 569-578 | Published online: 07 Jul 2009

Figures & data

Figure 1. Percent changes in mean arterial blood pressure in hypertensive group (open circles, n = 7) and nonhypertensive group (closed squares, n = 8) patients undergoing hemodialysis. *p<0.01 hypertensive group vs. nonhypertensive group.

Figure 1. Percent changes in mean arterial blood pressure in hypertensive group (open circles, n = 7) and nonhypertensive group (closed squares, n = 8) patients undergoing hemodialysis. *p<0.01 hypertensive group vs. nonhypertensive group.

Figure 2. Effects of recombinant human erythropoietin administration on plasma endothelin-1 levels in (□) hypertensive group (n = 7) and (▪) non-hypertensive group (n = 8) hemodialysis patients. Each column represents the mean ± SE. ET: endothelin.

Figure 2. Effects of recombinant human erythropoietin administration on plasma endothelin-1 levels in (□) hypertensive group (n = 7) and (▪) non-hypertensive group (n = 8) hemodialysis patients. Each column represents the mean ± SE. ET: endothelin.

Figure 3. Effects of recombinant human erythropoietin administration on plasma nitric oxide levels in (□) hypertensive group (n = 7) and (▪) nonhypertensive group (n = 8) hemodialysis patients. Each column represents the mean ± SE. NOx: nitric oxide product.

Figure 3. Effects of recombinant human erythropoietin administration on plasma nitric oxide levels in (□) hypertensive group (n = 7) and (▪) nonhypertensive group (n = 8) hemodialysis patients. Each column represents the mean ± SE. NOx: nitric oxide product.

Figure 4. Relation of changes in plasma endothelin-1 (A) or plasma nitric oxide (B) to changes in mean arterial blood pressure. Neither changes in plasma endothelin-1 levels (p = 0.154) nor changes in plasma nitric oxide product levels (p = 0.21) are related significantly to changes in mean arterial blood pressure. ET-1: endothelin-1, NOx: nitric acid product.

Figure 4. Relation of changes in plasma endothelin-1 (A) or plasma nitric oxide (B) to changes in mean arterial blood pressure. Neither changes in plasma endothelin-1 levels (p = 0.154) nor changes in plasma nitric oxide product levels (p = 0.21) are related significantly to changes in mean arterial blood pressure. ET-1: endothelin-1, NOx: nitric acid product.

Figure 5. Correlation between changes in plasma endothelin/nitric oxide product ratio and changes in mean arterial blood pressure in erythropoietin-induced hypertension. The relative change in mean arterial blood pressure after recombinant human erythropoietin administration was significantly related (p<0.05) to the relative change in plasma endothelin/nitric oxide ratio.

Figure 5. Correlation between changes in plasma endothelin/nitric oxide product ratio and changes in mean arterial blood pressure in erythropoietin-induced hypertension. The relative change in mean arterial blood pressure after recombinant human erythropoietin administration was significantly related (p<0.05) to the relative change in plasma endothelin/nitric oxide ratio.

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