Homocysteine in Renal Transplant Recipients: Association with Transplant Duration and Renal Function

Figures & data

Figure 1. Serum homocysteine level in renal transplant patients (N = 88, 76 males and 12 females) and control subjects (N = 60, 52 males and 8 females). ^*P < 0.001 versus respective controls ^#P < 0.05 versus female transplant and ^$P < 0.01 versus female controls, using Student's t‐test.

Figure 2. Correlation between serum total homocysteine levels and patients' age (hollow circles, r = − 0.066, P = 0.544), and transplant age (filled circles, r = 0.318, P < 0.01).

Table 1. Serum Biochemistry of Renal Transplant Patients and Normal Controls

Parameter	Transplant patients	Control subjects	Significance
	Mean + SE	Mean + SE
Albumin (g/L)	39.50 + 0.36	42.92 + 1.29	P < 0.001
Alkaline phosphatase (U/L)	286.73 + 20.97	179.77 + 6.21	P < 0.001
Alanine transferase (U/L)	32.34 + 2.96	33.03 + 2.52	NS
Bilirubin (umol/L)	14.89 + 0.95	10.07 + 0.79	P < 0.001
Calcium (mmol/L)	2.36 + 0.018	2.31 + 0.012	P < 0.05
Corrected calcium (mmol/L)	2.38 + 0.017	2.25 + 0.01	P < 0.001
Cholesterol (mmol/L)	5.87 + 0.14	4.77 + 0.13	P < 0.001
Creatinine (umol/L)	175.35 + 6.86	96.57 + 1.82	P < 0.001
Folate (nmol/L)	20.43 + 1.02	24.14 + 0.98	P < 0.05
Phosphate (mmol/L)	1.21 + 0.029	1.08 + 0.025	P < 0.01
Potassium (mmol/L)	4.51 + 0.058	4.29 + 0.06	P < 0.05
Sodium (mmol/L)	138.23 + 0.33	138.30 + 0.31	NS
Triglycerides (mmol/L)	2.50 + 0.13	2.38 + 0.21	NS
Urea (mmol/L)	12.14 + 0.64	4.69 + 0.14	P < 0.001
Vitamin B12 (pmol/L)	308.32 + 19.31	258.15 + 19.51	NS

Figure 3. Correlation between serum total homocysteine levels and serum urea, creatinine, vitamin B12 and potassium in renal transplant (left panel) and normal controls (right panel).