Effect of N‐Acetylcysteine on Antioxidant Status in Glycerol‐Induced Acute Renal Failure in Rats

Figures & data

Table 1. Results of Glutathione Reductase and Total Antioxidant Status in the Four Groups of the Experiment

	Group A (N = 10)	Group B (N = 10)	Group C (N = 10)	Group D (N = 10)
Glutathione reductase (U/L)	601 ± 148	208 ± 50	340 ± 130	443 ± 74
Total antioxidant status (mmol/L)	1.52 ± 0.21	1.38 ± 0.23	1.23 ± 0.17	0.32 ± 0.07

^*p < 0.05 between groups A and B. Group A: N‐acetylcysteine before rhabdomyolysis. Group B: placebo before rhabdomyolysis. Group C: N‐acetylcysteine after rhabdomyolysis. Group D: placebo after rhabdomyolysis.

Table 2. Glutathione Reductase and Total Antioxidant Status Levels in the Rats Administered with N‐Acetylcysteine or Placebo

	Group 1 (N = 20)	Group 2 (N = 20)
Glutathion reductase (U/L)	470 ± 189	356 ± 96
Total antioxidant status (mmol/L)	1.37 ± 0.23	1.35 ± 0.14

Group 1: administration of N‐acetylcysteine before and after rhabdomyolysis.

Group 2: administration of placebo before and after rhabdomyolysis.

Figure 1. Comparison of total antioxidant status (TAS) level in serum with the administration of N‐acetylcysteine (Nac) or placebo before rhabdomyolysis (Groups A and B).

Figure 2. Comparison of glutathione reductase (GR) levels in serum with the administration of N‐acetylcysteine (Nac) or placebo before rhabdomyolysis (Groups A and B).

Figure 3. Comparison of total antioxidant status (TAS) levels in serum among rats administered with N‐acetylcysteine (Group 1) and placebo (Group 2).

Figure 4. Comparison of glutathione reductase (GR) levels in serum among rats administered with N‐acetylcysteine (Group 1) and placebo (Group 2).