Psoriatic Nephropathy—Does an Entity Exist?

Figures & data

Table 1. Blood and Urine Biochemistry and Salient Clinical Characteristics of the Cases.

Characteristics	Case 1	Case 2	Case 3
Age	23 years	65 years	66 years
Duration of psoriasis	11 years	15 years	30 years
Significant anemia	Absent	Absent	Absent
Proteinuria (by dipstick)	3 +	4 +	4 +
RBCs/HPF in urine	10–12	10–12	1–2
Dysmorphic RBCs	60%	40%	Nil
WBCs/HPF in urine	1–2	2–3	0–1
Casts in urine	RBC, hyaline, granular, cylindroid, and mixed casts	RBC and granular casts	Cylindroid casts
24 h proteinuria	3.4 g	3.9 g	4.2 g
Blood urea	58	120	28
Serum creatinine	185 µmol/L	352 µmol/L	70 µmol/L
Serum sodium	135 meq/L	136 meq/L	138 meq/L
Serum potassium	4.5 meq/L	6.0 meq/L	4.2 meq/L
CRP > 6 ng/mL	Positive	Positive	Negative
ESR at end of first hour	45 mm	100 mm	98 mm
Total cholesterol	5.8 mmol/L	6 mmol/L	9.9 mmol/L
LDL-cholesterol	3.5 mmol/L	3.8 mmol/L	7.8 mmol/L
HDL-cholesterol	1.2 mmol/L	1.1 mmol/L	1 mmol/L
Serum triglycerides	1.8 mmol/L	2 mmol/L	2.4 mmol/L
Serum total proteins	45 g/L	45 g/L	48 g/L
Serum albumin	22 g/L	20 g/L	15 g/L

Figure 1. Kidney biopsy showing mesangioproliferative glomerulonephritis with mild increase in mesangial infiltration and patchy tubular atrophy. (Hematoxylin and Eosin, × 40).

Figure 2. Immunofluorescent staining of kidney biopsy tissue showing mesangial deposits of IgA.

Figure 3. Glomerulus in the field shows focal mesangial proliferation with neutrophil infiltration and fibrin deposition. (Hematoxylin and Eosin, × 40).

Figure 4. Membranous nephropathy showing thickened capillary walls, and numerous subepithelial “spikes” are present on the capillaries of the focused glomerulus. (Jones' silver stain, × 40).