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Journal of Liquid Chromatography & Related Technologies Volume 24, 2001 - Issue 11-12
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Original Articles

SCREENING NATURAL PRODUCTS: BIOASSAY-DIRECTED ISOLATION OF ACTIVE COMPONENTS BY DUAL-MODE CCC

Khisal A. Alvi New Chemical Entities Inc., 18804 North Creek Parkway South, Bothell, WA, 98011-8012, U.S.A.
Pages 1765-1773 | Received 22 Aug 2000, Accepted 12 Oct 2000, Published online: 06 Feb 2007
 
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Abstract

In the search of new chemical entities, we have developed an integrated biological-physiochemical system for the identification of active compounds in fermentation broths. The system relies upon preliminary fractionation of the microbial crude extract by dual mode high-speed countercurrent (HSCCC, PC Inc.) couple with photodiode array (PDA) detection and bioassay.

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