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Abstract
Monolithic columns, consisting of continuous beds with through pores of organic or inorganic matrix, have found increasing applications for HPLC separations. The main advantage of the monolithic technology is the ability to use high flow rates without significant loss of efficiency, leading to very fast separations. The size and shape of the monolith depends on the application. For HPLC, rods and discs made of silica or polymer have been applied. The silica monoliths have bimodal pore structure and large surface area. These have found applications for small molecule analysis. The polymer monoliths have smaller surface area and have been primarily used for the separation of macromoleculesCitation1 This paper discusses the recent applications of monolithic columns for HPLC separations.