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Journal of Liposome Research Volume 15, 2005 - Issue 1-2
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Research Article

Liposome Opsonization

Xuedong Yan Department of Cell Biology, Section Liposome Research, Groningen University Institute of Drug Exploration (GUIDE), Groningen, The Netherlands; Department of Pharmacokinetics and Drug Delivery, Groningen University Institute for Drug Exploration (GUIDE), Groningen, The Netherlands; Department of Pathology and Laboratory Medicine, Medical Biology Section, Groningen University Institute for Drug Exploration (GUIDE), Groningen, The Netherlands
,
Gerrit L. Scherphof Department of Cell Biology, Section Liposome Research, Groningen University Institute of Drug Exploration (GUIDE), Groningen, The Netherlands
&
Jan A. A. M. Kamps Department of Pathology and Laboratory Medicine, Medical Biology Section, Groningen University Institute for Drug Exploration (GUIDE), Groningen, The Netherlands
Pages 109-139 | Published online: 09 Dec 2008
 
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Abstract

Adsorption of serum proteins to the liposomal surface plays a critical role in the clearance of liposomes from the blood circulation. In this review, we will discuss the role of the liposomal opsonins proposed so far in liposome clearance. Additional, related topics that will be addressed are the cell-surface receptors that might be involved in liposome elimination from the blood compartment and the effect of poly(ethylene glycol) (PEG) modification on prevention of liposome opsonization.

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