Abstract
Condensation of the silylated pyrimidines 5a–c with methyl 2-deoxy-3,5-di-O-toluoyl-D-pentofuranoside 6, using trimethylsilyltriflate as catalyst gave anomeric mixtures of 2′-deoxynucleosides 7a–c, the pure α- and β-anomers were separated and deprotected with sodium methoxide in methanol to give 1-(2′-deoxy-α-D- pentafuranosyl)-4-hydroxy-5-substituted-6(1H)-pyrimidinones 10a,b and 13a and their corresponding β-anomers 11a,b and 13b.
Acknowledgments
DANIDA and the Danish Ministry of Foreign Affairs are gratefully acknowledged for financial support through the project “Development of New Drugs Against Hepatitis” at Monoufiya University.