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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 32, 2002 - Issue 3
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Original Articles

APPLICATION OF DEPBT FOR SYNTHESIS OF N-PROTECTED PEPTIDE ALCOHOLS AND ITS DERIVATIVES

Ping Liu Department of Chemistry, Key Laboratory of Bioorganic Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China
,
Bin-yuan Sun Department of Chemistry, Key Laboratory of Bioorganic Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China
,
Xiao-hua Chen Department of Chemistry, Key Laboratory of Bioorganic Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China
,
Gui-ling Tian Department of Chemistry, Key Laboratory of Bioorganic Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China
&
Yun-hua Ye Department of Chemistry, Key Laboratory of Bioorganic Chemistry and Molecular Engineering, Peking University, Beijing, 100871, ChinaCorrespondence[email protected]
Pages 473-480 | Received 19 Mar 2001, Published online: 16 Aug 2006
 
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ABSTRACT

A series of N-protected peptide alcohols and one N-glycopeptide derivative were synthesized using DEPBT. We showed that the carboxyl group selectively reacted with amino group of the amino component in the presence of unprotected hydroxy groups.

ACKNOWLEDGMENT

This work was supported by National Natural Science Foundation of China (No. 29872002)

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