ABSTRACT
A new chiral o-hydroxyaryldiazaphosphonodiamide 1 was synthesized from (−)-α-methylbenzylamine, it was found to be efficient ligand for the Ti(O-iPr)4 catalyzed asymmetric trimethylsilylcyanation of aldehydes. Corresponding aromatic cyanohydrins were obtained in good chemical yield and enantiomeric excesses (e.e.s) up to 90%.
ACKNOWLEDGMENT
We are grateful to the National Natural Science Foundation of China (No. 29872016 and 29725204) for the financial support.