ABSTRACT
A reinvestigation of the recently described method of synthesis of highly substituted 1,6-naphthyridines was carried out. It was found out that the reaction of chalcones with malononitrile catalysed by pyrrolidine afforded the mixture of four products both when thermal as well as microwave heating was used. The claimedCitation[1] 1,6-naphthyridines formation were exceptions.
ACKNOWLEDGMENTS
Our thanks are due to Dr. Eva Solčaniová for NMR measurements, Dr. Katerina Gáplovská (both of Institute of Chemistry, Faculty of Natural Sciences, Comenius University) for microanalysis and to the Slovak Grant Agency VEGA for financial support (Grant No. 1/7348/20).