ABSTRACT
Novel aryl thiophosphoramidate derivatives of the anti-HIV nucleoside analogue 3′-azido-3′-deoxythymidine (AZT) have been prepared by the thiophosphorochloridate chemistry. These materials were designed to act as membrane-soluble prodrugs of the bioactive free nucleotides.
ACKNOWLEDGMENT
The authors would like to thank the financial supports from the National Natural Science Foundation of China (No. 29902003, No. 39870415), the Ministry of Science and Technology, the Ministry of Education and Tsinghua University.