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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 33, 2003 - Issue 2
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Original Articles

New Synthesis of Optically Active α-Arylpropanoic Acid: The Asymmetric Hydrogenation of Atropic Acid over Cinchona-Modified Pd/Fe2O3 Catalysts

, &
Pages 175-182 | Received 10 Dec 2001, Published online: 21 Aug 2006
 

Abstract

The first satisfactory application of the heterogeneous cinchona-modified Pd/Fe2O3 catalyst system in the synthesis of optically active α-arylpropanoic acid, namely, the highly enantioselective (up to 87% ee) hydrogenation of atropic acid to S-(+)-naproxen is described.

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