A Convenient “One-Pot” Reaction for Selective Monoalkylation of N,N′-Disubstituted Ethylenediamines

Abstract

A study on the scope of the method to obtain N,N,N′-trisubstituted ethylenediamines III by monoalkylation of N,N′-disubstituted ethylenediamines I through a “one-pot” reaction is presented. It involves condensation of compounds I with aldehydes followed by reduction of the formed imidazolidines II without previous isolation.

Keywords:

• Disubstituted ethylenediamines
• Selective monoalkylation
• Imidazolidines
• Microwaves

Acknowledgment

This work was financially supported by the Universidad de Buenos Aires and CONICET.