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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 34, 2004 - Issue 2
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Original Articles

An Efficient Synthesis of Methyl 3-Carboxy-2-oxohexahydroazepine-1-acetate

, &
Pages 323-330 | Published online: 18 Oct 2011
 

Abstract

The title compound 1 is prepared from ε-caprolactam in a five-step sequence involving N-alkylation of the azepine ring from a 3-(phenylselanyl)-3-(benzyloxycarbonyl) derivative 4 and the generation of the 3-carboxyazepine moiety from the resulting diester 5 by ozonolysis followed by catalytic hydrogenation.

Acknowledgment

Thanks are due to the DURSI, Generalitat de Catalunya, for Grant 2001SGR-0084.

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