Abstract
Preparation and ring-closure of 2-dimethylaminomethylene-5-substituted-3-oxo-pent-4-enoic acid benzyl esters to dihydropyridine rings are efficiently and quickly carried out under solvent-free conditions in an open-vessel microwave system. The syntheses of 1,6-disubstituted-4-oxo-1,4,5,6-tetrahydro-pyridine-3-carboxylic acid benzyl esters are reported.
Acknowledgments
This work was partially supported by “Progetto Strategico sulle applicazioni delle Microonde, CNR, Rome.”
Notes
aWork is in progress to delucidate this surprising high stereoinduction. The results will be reported in due course.