Abstract
A short and facile synthesis of a series of 3‐aryl quinazolin‐4‐(3H)‐ones was accomplished in good yields via the intermolecular reductive coupling reaction of N‐aryl‐2‐nitrobenzamide and triethyl orthoformate promoted by TiCl4/Zn.
Acknowledgments
We are grateful to the Education Committee Nature Science Foundation of Jiangsu Province and the Key Laboratory of Organic Synthesis, Suzhou University for financial support.
Notes
aX‐ray crystallography for 3a: Empirical formula C14H10N2O, F W = 222.24, T = 297(2) K, moloclinic, space group P2(1)/c, a = 12.080(2) Å, b = 7.793(1) Å, c = 11.599(1) Å, β = 97.56(1)°, V = 1082.4(2) Å3, Z = 4, Dc = 1.364 mg/m3, λ(Mo Kα) = 0.71073 Å, μ = 0.088 mm−1, F(0 0 0) = 464. 170° < θ < 25.25°, R = 0.0358, wR = 0.0851, S = 0933. Largest diff. Peak and hole: 0.130 and −0.117e Å−3.