Synthesis of 4‐Arylpiperazine Derivatives of Moclobemide: Potential Antidepressants with a Dual Mode of Action

Abstract

We report here the synthesis of substituted 4‐chloro‐N‐[3‐oxo‐3‐(4‐aryl‐1‐piperazinyl)‐propyl] benzamides (5–9), as potential new antidepressants, incorporating in a single molecule structural moieties related to a dual pharmacological profile: MAO‐A inhibitor and 5‐HT_1A receptor affinity.

Acknowledgments

This work was supported by the Research Project CEPEDEQ‐ FACULTAD of the Chemical and Pharmaceutical Sciences Faculty, University of Chile, Santiago, Chile, and FONDECYT 1030916.