A Novel One‐Pot Synthesis of 2‐Aryl‐4(3H)‐Quinazolinones Using Room Temperature Ionic Liquid as Reaction Medium as well as Promoter

Abstract

An efficient one‐pot synthesis of 2‐aryl‐4(3H)‐quinazolinones from 2‐amino benzamides and substituted benzoyl chlorides in a room temperature ionic liquid is described. Compared with the classical reaction conditions, this new synthetic method has the advantages of recyclability of ionic liquid, very good to excellent yields (78–92%), the absence of hazardous and expensive catalysts, and easy workup procedures giving rise to a process with minimum waste.

Keywords:

• Ionic liquid
• 2‐amino benzamide
• benzoyl chlorides
• 2‐aryl‐4(3H)‐quinazolinones

Acknowledgments

TMP thanks CSIR, New Delhi, for providing a Junior Research Fellowship. The authors also acknowledge financial assistance from Department of Science and Technology (DST), New Delhi, vide Project No. SR/S5/OC‐23/2002).