A Novel Three‐Component Synthesis of Triazinothiazolones

Abstract

A series of 4‐arylidene‐2‐methyloxazol‐5‐ones 1 were condensed with thiosemi‐carbazide to yield 6‐arylmethyl‐3‐mercapto‐1,2,4‐triazin‐5‐ones 2. The resulting mercapto triazinones 2 were condensed with monochloroacetic acid and 5‐aryl‐furan‐2‐carboxaldehydes 3 in a one‐pot three‐component reaction in the presence of acetic anhydride, acetic acid, and sodium acetate to yield 4‐substituted‐5‐oxo‐7‐(5‐aryl‐2‐furfurylidene)‐1,2,4‐triazino[3,4‐b]‐thiazol‐6‐ones 4. Some of the newly synthesized compounds were tested for their antibacterial activity against Gram (+)ve and Gram (−)ve bacteria. The results of such studies are discussed in this paper.

Keywords:

• Three component reaction
• triazinothiazolones
• MCRs
• antibacterial activity

Acknowledgment

The authors are thankful to the Director, RSIC, Punjab University, Chandigarh, The Head RSIC, CDRI Lucknow and the Head, RSIC, IIT Chennai for elemental and spectral analysis. The authors are also thankful to Dr. N. Suchetha Kumari, K.S. Hegde Medical Academy, Deralakatte, Mangalore for arranging the antibacterial activity studies reported in this paper. One of the authors K.V. Malini is thankful to UGC, New Delhi for the award of Teacher Fellowship under Faculty Improvement Programme.