Abstract
New chiral NiII complex of the dehydroaminobutanoic acid Schiff base with (S)‐N‐(2‐benzoylphenyl)‐1‐(3,4‐dichlorbenzyl)pyrrolidyl‐2‐carboxamide (CPB) was synthesized and tested as electrophile component in the asymmetric Michael addition reactions with nucleophiles (imidazole, benzylamine, methoxy ion, ethoxy ion). The method of the asymmetric synthesis of β‐substituted (S)‐α‐amino acids with high d.e > 80% was developed.
Acknowledgments
The authors are grateful to Prof. Yu.N. Belokon' for fruitful discussion during the preparation of the manuscript. The research described was supported by the ISTC grant 2780.