Novel Process for Synthesis of 1,2,4‐Triazoles: Ytterbium Triflate–Catalyzed Cyclization of Hydrazonyl Chlorides with Nitriles

Abstract

A series of 1,3,5‐trisubstituted 1,2,4‐triazoles were synthesized via the intermolecular cyclization of hydrazonyl chlorides with nitriles catalyzed by ytterbium triflate [Yb(OTf)₃]. The amount of catalysis was discussed and Yb(OTf)₃ could be reused without loss of activity.

Keywords:

• Cyclization
• hydrazonyl chlorides
• nitriles
• triazoles
• ytterbium triflate

Acknowledgments

We are grateful to the National Natural Science Foundation of China (No. 20276072), National Basic Research Program (No.2003CB114400), and National Natural Science Foundation of Zhe Jiang Province (No. 2002095) for financial support.