SYNTHESIS, CHARACTERIZATION, AND BIOLOGICAL ACTIVITIES OF RUTHENIUM(II) CARBONYL COMPLEXES CONTAINING BIFUNCTIONAL TRIDENTATE SCHIFF BASES

Abstract

Ruthenium(II) carbonyl complexes have been synthesised by reacting [RuH₂(CO)(PPh₃)₃] or [RuHCl(CO)(PPh₃)₂(Z)] (Z = PPh₃, pyridine (py) or piperidine (pip)) with tridentate Schiff base ligands derived by condensing salicylaldehyde, o-vanillin or o-hydroxyacetophenone with N(4)-phenylsemicarbazide. These complexes have been characterised by analytical, IR, electronic, ¹H NMR and ³¹P NMR spectral studies. The complexes of the general formula [Ru(L)(CO)(PPh₃)(Z)] (L = Schiff base anion; Z = PPh₃, py or pip) tentatively have been assigned an octahedral structure. Some of the complexes have been tested for in vitro growth inhibitory activity against the bacteria Escherichia coli, Bacillus sp. and Pseudomonas sp.

ACKNOWLEDGMENT

One of us (C.J.B.) is thankful to the University Grants Commission, New Delhi, India for the award of a Teacher Research Fellowship.