Single nucleotide polymorphism (SNP) analysis demonstrates a significant association of tumour necrosis factor-alpha (TNFA) with primary immune thrombocytopenia among Caucasian adults

Ameet SarpatwariDepartment of Public Health and Primary CareUniversity of Cambridge, Cambridge, UK;Department of HaematologyBarts and The London School of Medicine and Dentistry, London, UKCorrespondence[email protected]

James B BusselDepartment of PediatricsWeil Medical College of Cornell University, New York, USA

Momin AhmedDepartment of HaematologyBarts and The London School of Medicine and Dentistry, London, UK

Sebhat ErqouDepartment of Public Health and Primary CareUniversity of Cambridge, Cambridge, UK

John W SempleKeenan Research Centre, Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, Canada

Adrian C NewlandDepartment of HaematologyBarts and The London School of Medicine and Dentistry, London, UK

Dimitri BennettOncology EpidemiologyGlaxoSmithKline, Philadelphia, PA, USA

Paul PharoahDepartment of Public Health and Primary CareUniversity of Cambridge, Cambridge, UK

Drew ProvanDepartment of HaematologyBarts and The London School of Medicine and Dentistry, London, UK

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Figures & data

**Table 1. Observed genotype frequencies and SNP–disease, Helicobacter pylori infection, and severity association results**

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Figure 1. Results of logistic regression modelling of associations between six functional, candidate SNPs and primary using a sample of 206 Caucasian adults with primary ITP gender-matched with 618 healthy Caucasian controls. A statistically significant association was observed between the disease and TNFA −308 g>a.

Figure 2. Results of logistic regression modelling of associations between six functional, candidate and both disease severity and H. pylori infection in Caucasian adults with primary ITP. No statistically significant associations were observed.

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Single nucleotide polymorphism (SNP) analysis demonstrates a significant association of tumour necrosis factor-alpha (TNFA) with primary immune thrombocytopenia among Caucasian adults

**Table 1. Observed genotype frequencies and SNP–disease, Helicobacter pylori infection, and severity association results**

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Single nucleotide polymorphism (SNP) analysis demonstrates a significant association of tumour necrosis factor-alpha (TNFA) with primary immune thrombocytopenia among Caucasian adults

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Table 1. Observed genotype frequencies and SNP–disease, Helicobacter pylori infection, and severity association results

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**Table 1. Observed genotype frequencies and SNP–disease, Helicobacter pylori infection, and severity association results**