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LYMPHOPROLIFERATIVE DISEASE

Clinical features of de novo CD25+ diffuse large B-cell lymphoma

, , , , , , , , , , & show all
Pages 14-19 | Published online: 18 Jul 2013

Figures & data

Figure 1. CD25 expression in DLBCL. DLBCL cells are identified by forward and side scatter properties, and CD25 expression on the cells is shown using two-color flow cytometry (A). There is no relationship between CD25-positivity and one of CD3, CD4, and CD8-positivity (B) in the gated regions. r, correlation coefficient.

Figure 1. CD25 expression in DLBCL. DLBCL cells are identified by forward and side scatter properties, and CD25 expression on the cells is shown using two-color flow cytometry (A). There is no relationship between CD25-positivity and one of CD3, CD4, and CD8-positivity (B) in the gated regions. r, correlation coefficient.

Figure 2. Kaplan–Meier estimates of PFS (A) and OS (B)for DLBCL patients treated with R-CHOP in accordance with CD25-positivity. According to CD25-positivity in the gated regions, three groups are clearly separated: more than 60%, 20–60%, and less than 20% CD25-positivity.

Figure 2. Kaplan–Meier estimates of PFS (A) and OS (B)for DLBCL patients treated with R-CHOP in accordance with CD25-positivity. According to CD25-positivity in the gated regions, three groups are clearly separated: more than 60%, 20–60%, and less than 20% CD25-positivity.

Table 1. Patient characteristics according to CD25 expression

Figure 3. Kaplan–Meier estimates of PFS (A) and OS (B) for patients with CD25-high and CD25-low DLBCL treated with R-CHOP. CD25-high and CD25-low indicate 60% or more CD25-positivity in the gated regions and less than 60% positivity in the regions, respectively.

Figure 3. Kaplan–Meier estimates of PFS (A) and OS (B) for patients with CD25-high and CD25-low DLBCL treated with R-CHOP. CD25-high and CD25-low indicate 60% or more CD25-positivity in the gated regions and less than 60% positivity in the regions, respectively.

Table 2. Response to R-CHOP chemotherapy

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